MECHANISM OF A REACTION IN VITRO ASSOCIATED WITH DELAYED-TYPE HYPERSENSITIVITY
MECHANISM OF A REACTION IN VITRO ASSOCIATED WITH DELAYED-TYPE HYPERSENSITIVITY
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DOI：
10.1126/science.153.3731.80
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发表时间：
1966-01-01
期刊：
影响因子：
56.9
通讯作者：
BENNETT, B
中科院分区：
文献类型：
--
作者：
BLOOM, BR;BENNETT, B
研究了结核菌素过敏豚鼠腹膜渗出细胞在体外受抗原迁移抑制的细胞类型。渗出细胞群分为淋巴细胞和巨噬细胞组成细胞。来自敏感供体的腹膜淋巴细胞是该系统的免疫活性细胞，巨噬细胞只是迁移的指示细胞。致敏的腹膜淋巴细胞群在体外与特定抗原相互作用后，在培养基中形成一种能够抑制正常渗出细胞迁移的可溶性物质。
The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied. Exudate populations were separated into component cell types, the lymphocyte and the macrophage. Peritoneal lymphocytes from sensitive donors were the immunologically active cells in this system, the macrophages being merely indicator cells which migrate. Sensitized peritoneal lymphocyte populations, upon interaction with specific antigen in vitro, elaborated into the medium a soluble material capable of inhibiting migration of normal exudate cells.