Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins
Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins
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DOI：
10.1016/j.tet.2008.01.142
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发表时间：
2008-04-14
期刊：
影响因子：
2.1
通讯作者：
Frochot, Celine
中科院分区：
文献类型：
--
作者：
Boisbrun, Michel;Vanderesse, Regis;Frochot, Celine
报告了与 RGD 型肽偶联的四苯卟啉和四苯二氯的合成、表征、荧光和单线态氧量子产率。通过高效的收敛过程，在克级液相中合成了 C 末端受保护的 RGD 衍生物。 C 端未保护的 RGD 衍生物在固相支持物上合成。紫外可见光谱、荧光光谱和单线态发射光谱表明，所有化合物都保留了光敏剂的光物理性质，其中一些化合物在潜在的 PDT 应用中非常有前景。 (c) 2008 Elsevier Ltd. 保留所有权利。
The synthesis, characterization, fluorescence, and singlet oxygen quantum yields of tetraphenylporphyrin and tetraphenylchlorin coupled to RGD type peptide are reported. C-terminus protected RGD derivatives were synthesized in liquid phase at the gram scale via an efficient convergent process. C-terminus unprotected RGD derivatives were synthesized on solid support. The UV-vis, fluorescence, and singlet emission spectra showed that the photophysical properties of the photosensitizers were retained in all compounds and some of them are very promising for potential PDT applications. (c) 2008 Elsevier Ltd. All rights reserved.