Attention deficit disorder symptoms and urine catecholamines.
Attention deficit disorder symptoms and urine catecholamines.
复制标题
注意力缺陷障碍症状和尿液儿茶酚胺。
DOI：
10.1016/0165-1781(89)90140-6
复制
发表时间：
1989
影响因子：
11.3
通讯作者：
Harris,WR
中科院分区：
文献类型：
--
作者：
Rogeness,GA;Maas,JW;Javors,MA;Macedo,CA;Fischer,C;Harris,WR
与注意力缺陷障碍(ADD)相关的多动、冲动和注意力不足的症状可能部分与多巴胺和去甲肾上腺素能功能的改变有关。在这项研究中，我们将情绪障碍男孩的上述症状与24小时尿儿茶酚胺及其代谢物相关，根据他们的血浆多巴胺-β-羟基酶(DBH)活性分为两组，并将其分为以下诊断组：品行障碍，社交不足；品行障碍，社交；以及无品行障碍的受试者。低胸径组男童ADD症状与生化指标呈显著正相关。低胸径组在儿茶酚胺功能方面的遗传同质性可能更高，这使得儿茶酚胺功能与行为之间的关系更加明显。有品行障碍的男孩组，社会化的24小时尿去甲肾上腺素和香草扁桃酸排出量较高。单胺及其代谢物之间的关系似乎在不同的诊断小组之间有所不同。
The symptoms of hyperactivity, impulsivity, and concentration deficits associated with attention deficit disorder (ADD) may be related, in part, to alterations in dopaminergic and noradrenergic functioning. In this study we correlate the above symptoms with 24-hour urinary catecholamines and their metabolites in emotionally disturbed boys divided into two groups based on their plasma dopamine-β-hydroxylase (DBH) activities and also divided into the following diagnostic groups: conduct disorder, undersocialized; conduct disorder, socialized; and subjects without conduct disorder. Boys in the low DBH group showed significant correlations between the ADD symptoms and the biochemical measures. The low DBH group may be more genetically homogeneous with regard to catecholamine function, making relationships between catecholamine function and behavior more visible. The group of boys with conduct disorder, socialized had higher 24-hour urinary norepinephrine and vanillylmandelic acid output. The relationship between monoamines and their metabolites appeared to differ among diagnostic groups.