Characterization of the discrepancies between four-dimensional phase-contrast magnetic resonance imaging and in-silico simulations of cerebrospinal fluid dynamics.
Characterization of the discrepancies between four-dimensional phase-contrast magnetic resonance imaging and in-silico simulations of cerebrospinal fluid dynamics.
复制标题
四维相衬磁共振成像与脑脊液动力学计算机模拟之间差异的表征。
DOI：
10.1115/1.4029699
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Martin,BrynA
中科院分区：
文献类型：
--
作者：
HeidariPahlavian,Soroush;Bunck,AlexanderC;Loth,Francis;ShaneTubbs,R;Yiallourou,Theresia;Kroeger,JanRobert;Heindel,Walter;Martin,BrynA
本研究的目的是比较特定受试者的磁共振成像（MRI）为基础的计算流体动力学（CFD）模拟与时间分辨的三向（3D）速度编码相衬MRI（4D PCMRI）测量的脑脊液（CSF）的速度场在颈椎蛛网膜下腔（SSS）。基于MRI图像分割和解剖测量，构建了一名健康受试者和一名基亚里I畸形患者的颈部上矢状窦的三维模型。CFD用于模拟CSF运动，并与4D PCMRI测量结果进行比较。与CFD模拟相比，四维PCMRI测量的CSF速度更大（1.4至5.6倍）。四维PCMRI和CFD均显示CSF速度的前部和前外侧优势，尽管与CFD相比，这种流动特征在4D PCMRI测量中更明显。在CFD模拟中，神经根和齿状韧带（NRDL）附近存在CSF射流。在4D PCMRI测量中可以看到流动射流，尽管它们不能清楚地归因于神经根。将脊髓NRDL纳入颈椎SSS并不能完全解释从4D PCMRI测量和CFD模拟获得的速度之间的差异。
The purpose of the present study was to compare subject-specific magnetic resonance imaging (MRI)-based computational fluid dynamics (CFD) simulations with time-resolved three-directional (3D) velocity-encoded phase-contrast MRI (4D PCMRI) measurements of the cerebrospinal fluid (CSF) velocity field in the cervical spinal subarachnoid space (SSS). Three-dimensional models of the cervical SSS were constructed based on MRI image segmentation and anatomical measurements for a healthy subject and patient with Chiari I malformation. CFD was used to simulate the CSF motion and compared to the 4D PCMRI measurements. Four-dimensional PCMRI measurements had much greater CSF velocities compared to CFD simulations (1.4 to 5.6× greater). Four-dimensional PCMRI and CFD both showed anterior and anterolateral dominance of CSF velocities, although this flow feature was more pronounced in 4D PCMRI measurements compared to CFD. CSF flow jets were present near the nerve rootlets and denticulate ligaments (NRDL) in the CFD simulation. Flow jets were visible in the 4D PCMRI measurements, although they were not clearly attributable to nerve rootlets. Inclusion of spinal cord NRDL in the cervical SSS does not fully explain the differences between velocities obtained from 4D PCMRI measurements and CFD simulations.