TIME OF ORIGIN OF CORRESPONDING CELL CLASSES IN CEREBRAL-CORTEX OF NORMAL AND REELER MUTANT MICE - AUTORADIOGRAPHIC ANALYSIS
TIME OF ORIGIN OF CORRESPONDING CELL CLASSES IN CEREBRAL-CORTEX OF NORMAL AND REELER MUTANT MICE - AUTORADIOGRAPHIC ANALYSIS
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DOI：
10.1002/cne.901480202
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发表时间：
1973-01-01
影响因子：
2.5
通讯作者：
SIDMAN, RL
中科院分区：
文献类型：
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作者：
CAVINESS, VS;SIDMAN, RL
Reeler是一种小鼠隐性突变，可导致大脑和小脑皮质的细胞结构异常。虽然大脑皮质中细胞类别的相对位置明显异常，但放射自显影标准显示，每类细胞的起源时间似乎正常。在海马后皮质结构和相邻的新皮质，最早产生的细胞类，多态性，出现在相同的胚胎时间在正常和reeler窝。而这些细胞形成正常皮层的最深层，它们位于突变体的软膜下位置，没有细胞稀疏的外部丛状（分子）层。接着产生一群较大的细胞;这些细胞通常位于更表层，但在突变体中位于多态细胞的深处。新皮质的颗粒细胞出现最后，同时在正常和reeler;他们形成最表面的新皮质细胞层在正常的，但在突变体中位于更受限制的水平内的大细胞区。这些数据表明，细胞结构的异常，在reeler是独立的时空程序的细胞生成。看起来，卷轴遗传位点可能控制着胚胎事件，但尚未确定，指导有丝分裂后迁移的年轻神经元在皮层内的类特异性水平。
Reeler, a recessive mutation in mice, causes cytoarchitectonic abnormalities of the cerebral and cerebellar cortices. Although the relative positions of classes of cells in the cerebral cortex are markedly abnormal, the time of origin of cells in each class appears to be normal by autoradiographic criteria. In the retrohippocampal cortical structures and in the adjacent neocortex, the earliest generated cell class, the polymorphic, arises at the same embryonic time in normal and reeler littermates. Whereas these cells come to form the deepest stratum of the normal cortex, they lie in an immediately subpial position in the mutant, there being no cell‐sparse external plexiform (molecular) layer. A population of larger cells is generated next; these normally come to lie in more superficial layers but instead lie deep to the polymorphic cells in the mutant. Granule cells of the neocortex arise last, simultaneously in normal and reeler; they form the most superficial neocortical cell stratum in the normal, but lie at a more restricted level within the large cell zone in the mutant. These data indicate that the cytoarchitectonic anomaly in reeler is independent of the spatiotemporal program of cell generation. It appears likely that the reeler genetic locus governs embryonic events, as yet undefined, that direct the postmitotic migrating young neuron to class‐specific levels within the cortex.