Glycinergic Inhibitory Plasticity in Binaural Neurons Is Cumulative and Gated by Developmental Changes in Action Potential Backpropagation.
Glycinergic Inhibitory Plasticity in Binaural Neurons Is Cumulative and Gated by Developmental Changes in Action Potential Backpropagation.
复制标题
双耳神经元中的甘氨酸能抑制可塑性是累积的，并由动作电位反向传播的发育变化控制。
DOI：
10.1016/j.neuron.2018.03.001
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发表时间：
2018
期刊：
影响因子：
16.2
通讯作者：
Golding,NaceL
中科院分区：
文献类型：
--
作者：
Winters,BradleyD;Golding,NaceL
内侧上级橄榄核（MSO）神经元对基于时间的声音定位线索的利用严重依赖于甘氨酸能抑制输入。听力发作后，这些抑制性输入的强度和亚细胞位置发生了显着变化，但这种依赖经验的细化背后的细胞过程是未知的。在这里，我们揭示了MSO神经元的抑制性长时程增强（iLTP）的一种形式，它依赖于尖峰和突触激活，但不受其在听觉回路中普遍存在的较高频率下的精细尺度相对定时的影响。我们发现，iLTP加强抑制性输入与双耳兴奋共同作用的累积方式，可能非常适合具有持续的高频活动的网络。我们还表明，动作电位大小和反向传播的急剧下降限制了诱导的iLTP的前2周的听力。这些内在的变化将剥夺更远端的抑制性突触的强化，可以想象建立成熟的、体细胞偏向的抑制模式。
Utilization of timing-based sound localization cues by neurons in the medial superior olive (MSO) depends critically on glycinergic inhibitory inputs. After hearing onset, the strength and subcellular location of these inhibitory inputs are dramatically altered, but the cellular processes underlying this experience-dependent refinement are unknown. Here we reveal a form of inhibitory long-term potentiation (iLTP) in MSO neurons that is dependent on spiking and synaptic activation but is not affected by their fine-scale relative timing at higher frequencies prevalent in auditory circuits. We find that iLTP reinforces inhibitory inputs coactive with binaural excitation in a cumulative manner, likely well suited for networks featuring persistent high-frequency activity. We also show that a steep drop in action potential size and backpropagation limits induction of iLTP to the first 2 weeks of hearing. These intrinsic changes would deprive more distal inhibitory synapses of reinforcement, conceivably establishing the mature, soma-biased pattern of inhibition.