Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
复制标题
DOI：
10.1016/j.febslet.2015.03.031
复制
发表时间：
2015-05-08
期刊：
影响因子：
3.5
通讯作者：
Ochi, Mitsuo
中科院分区：
文献类型：
--
作者：
Nakamura, Yoshihiro;Miyaki, Shigeru;Ochi, Mitsuo
间充质干细胞（MSC）移植用于治疗多种疾病。MSC在组织再生中的旁分泌作用引起了特别的关注。我们研究MSC外泌体在骨骼肌再生中的作用。MSC外泌体在体外促进肌生成和血管生成，并在肌肉损伤的体内模型中促进肌肉再生。虽然MSC外泌体具有低浓度的肌肉修复相关细胞因子，但鉴定了许多修复相关的miRNA。这项研究表明，MSC衍生的外泌体通过增强肌生成和血管生成来促进肌肉再生，这至少部分是由miRNA如miR-494介导的。(C)2015年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.