Modular networks and cumulative impact of lateral transfer in prokaryote genome evolution
Modular networks and cumulative impact of lateral transfer in prokaryote genome evolution
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DOI：
10.1073/pnas.0800679105
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发表时间：
2008-07-22
影响因子：
11.1
通讯作者：
Martin, William
中科院分区：
文献类型：
--
作者：
Dagan, Tal;Artzy-Randrup, Yael;Martin, William
基因横向转移是原核生物自然变异的一个重要机制，但其对基因组进化的数量贡献的意义存在争议。在这里，我们报告了在分布在181个测序的原核基因组中的539，723个基因中捕获进化历史的纵向和横向成分的网络。通过本征谱分析对这些网络进行分区，识别原核生物基因共享网络中的社区结构，其模块不对应于严格的原核生物分层分类。我们的研究结果表明，平均而言，每个研究的基因组中至少有81 +/- 15%的基因在其历史的某个时刻参与了横向基因转移，即使它们在获得后可以垂直遗传，揭示了横向基因转移在较长进化时间尺度上的大量累积效应。
Lateral gene transfer is an important mechanism of natural variation among prokaryotes, but the significance of its quantitative contribution to genome evolution is debated. Here, we report networks that capture both vertical and lateral components of evolutionary history among 539,723 genes distributed across 181 sequenced prokaryotic genomes. Partitioning of these networks by an eigenspectrum analysis identifies community structure in prokaryotic gene-sharing networks, the modules of which do not correspond to a strictly hierarchical prokaryotic classification. Our results indicate that, on average, at least 81 +/- 15% of the genes in each genome studied were involved in lateral gene transfer at some point in their history, even though they can be vertically inherited after acquisition, uncovering a substantial cumulative effect of lateral gene transfer on longer evolutionary time scales.