Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease
Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease
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DOI：
10.1016/j.trsl.2008.11.008
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发表时间：
2009-02-01
影响因子：
7.8
通讯作者：
Ishibashi, Hiromi
中科院分区：
文献类型：
--
作者：
Migita, Kiyoshi;Sawakami-Kobayashi, Kazumi;Ishibashi, Hiromi
本研究旨在探讨白细胞介素-18（IL-18）基因启动子多态性是否与B型肝炎病毒（HBV）感染的预后相关。在这项研究中，总共招募了204名慢性HBV感染者。在204例HBV感染患者中，根据血清丙氨酸氨基转移酶（ALT）持续正常化以及抗B e-抗原（抗-HBe）抗体血清阳性，43例被认为是非活动性HBV携带者。共有161名患者被发现患有慢性进行性肝病，其中包括肝硬化。HBV携带者IL-18基因启动子-607位点AA基因型和-137位点C等位基因频率显著高于慢性进展性肝病患者。IL-18启动子区的这些多态性（-607和-137）可能与HBV感染的不同结果相关。（翻译研究2009;153：91-96）
In this study, we aimed to explore whether interleukin-18 (IL-18) gene-promoter polymorphisms are associated with the outcome of hepatitis B virus (HBV) infection. In all, 204 chronically HBV-infected patients were recruited in this study. Of the 204 HBV-infected patients, 43 were considered to be inactive HBV carriers based on the sustained normalization of serum alanine aminotransferase (ALT) together with seropositivity for the antibody to hepatitis B e-antigen (anti-HBe). A total of 161 patients were found to have chronic progressive liver disease, which included cirrhosis. In these HBV-infected patients, the frequencies of AA genotype of IL-18 gene-promoter polymorphisms at position -607 and C allele at position -137 were significantly higher in inactive HBV carriers compared with those in patients with chronic progressive liver disease. These polymorphisms of the IL-18 promoter regions (-607 and -137) could be associated with different outcomes of HBV infection. (Translational Research 2009;153:91-96)