ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases
ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases
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DOI：
10.1128/aac.01801-18
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发表时间：
2019-01-01
影响因子：
4.9
通讯作者：
Bonomo, Robert A.
中科院分区：
文献类型：
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作者：
Jacobs, Michael R.;Abdelhamed, Ayman M.;Bonomo, Robert A.
铁载体头孢菌素头孢菌素的活性针对耐碳青霉烯类革兰氏阴性菌。在这项研究中，通过在贫铁 Mueller-Hinton 肉汤中进行微量稀释，测定了头孢地罗对抗特征性碳青霉烯类耐药鲍曼不动杆菌复合体、嗜麦芽寡养单胞菌、铜绿假单胞菌和肠杆菌科菌株的活性。针对鲍曼不动杆菌、嗜麦芽胞杆菌和铜绿假单胞菌的 MIC90 值分别为 1、0.25 和 0.5 毫克/升。对于肠杆菌科细菌，对于含有OXA-48样的组，MIC90为1毫克/升，对于含有KPC-3的组，MIC90为2毫克/升，对于含有TEM/SHV ESBL、NDM和KPC-2的组，MIC90为8毫克/升。
The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.