Caffeine Consumption in First-Degree Relatives of Essential Tremor Cases: Evidence of Dietary Modification Before Disease Onset.
Caffeine Consumption in First-Degree Relatives of Essential Tremor Cases: Evidence of Dietary Modification Before Disease Onset.
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原发性震颤病例一级亲属的咖啡因摄入量：疾病发作前饮食调整的证据。
DOI：
10.1159/000489960
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发表时间：
2018
影响因子：
5.7
通讯作者：
Factor-Litvak,Pam
中科院分区：
文献类型：
--
作者：
Louis,ElanD;Meyers,JamesH;Cristal,AshleyD;Factor-Litvak,Pam
背景：咖啡因可加重震颤。减少咖啡因的摄入或改用无咖啡因的饮料可以减轻震颤。特发性震颤（ET）病例的未受影响的亲属通常有轻微的亚临床震颤。一个问题是，是否在这些人的咖啡和茶的消费模式不同，从控制（公司）。方法：我们确定了咖啡和茶的摄入模式，使用结构化问卷调查，并比较使用未受影响的一级亲属的ET病例（FD-ET）的使用年龄匹配的公司。三个措施的相对含咖啡因的咖啡+茶脱咖啡因的咖啡+茶构建。咖啡因指数1 =（含咖啡因咖啡+茶的杯数）-（无咖啡因咖啡+茶的杯数）。咖啡因指数2 =（含咖啡因的咖啡杯数+茶）-（脱咖啡因的咖啡杯数+茶）。结果：有263人（FD-ET 190人，Co 73人）。FD-ET中的咖啡因指数1小于Co的一半（p= 0.001）。FD-ET中的咖啡因指数2同样低于Co（p= 0.027）。在一个典型的月份中，咖啡和茶中含有咖啡因的百分比也显着低于FD-ET比Co（p= 0.018）。结论：含咖啡因的饮料的平衡是不同的FD-ET比Co。这些数据提出了几个有趣的问题。其中之一是ET病例的亲属是否在疾病发作前改变了他们的咖啡因摄入量。
Background:Caffeine can exacerbate tremor. Reducing caffeine intake or switching to decaffeinated beverages can lessen tremor. Unaffected relatives of essential tremor (ET) cases often have mild, subclinical tremor. One question is whether the coffee and tea consumption pattern in these individuals differs from that of controls (Co).Methods:We ascertained the patterns of coffee and tea intake using a structured questionnaire, and compared the use in unaffected first-degree relatives of ET cases (FD-ET) to the use in age-matched Co. Three measures of relative caffeinated coffee + tea to decaffeinated coffee + tea were constructed. Caffeine index 1 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed on the day of evaluation. Caffeine index 2 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed in a typical month. The percentage of coffee and tea that was caffeinated in a typical month was also calculated.Results:There were 263 individuals (190 FD-ET, 73 Co). Caffeine index 1 in FD-ET was less than 1-half that of Co (p= 0.001). Caffeine index 2 was similarly lower in FD-ET than Co (p= 0.027). The percentage of coffee and tea that was caffeinated in a typical month was also significantly lower in FD-ET than Co (p= 0.018).Conclusion:The balance of caffeinated to decaffeinated beverages is different in FD-ET than Co. These data raise several intriguing questions. Among these is whether relatives of ET cases modify their caffeine consumption before disease onset.