Structure and biosynthesis of FD-594; a new antitumor antibiotic
Structure and biosynthesis of FD-594; a new antitumor antibiotic
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DOI：
10.7164/antibiotics.51.288
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发表时间：
1998-03-01
影响因子：
3.3
通讯作者：
Qiao, YF
中科院分区：
文献类型：
--
作者：
Kondo, K;Eguchi, T;Qiao, YF
由Streptomyces sp. TA-0256合成的新型抗肿瘤抗生素FD-594(1)，通过光谱数据确定其结构为糖基化吡喃[4′，3′：6,7]萘[1,3-b]杂蒽骨架。通过[1- c -13]-、[2- c -13]-和[1,2- c -13(2)]乙酸钠的投料实验，对1的发色团进行了生物合成研究。通过C-13 NMR（包括2D不充分实验）确定了标记模式，这使我们能够阐明1的发色团来源于14醋酸盐。然后失去一个碳原子。
The structure of a novel antitumor antibiotics FD-594 (1), produced by Streptomyces sp. TA-0256, was determined to have a glycosylated pyrano[4',3': 6,7]naphtho[1,3-b]xanthene skeleton by means of spectral data. The biosynthetic studies of the chromophore of 1 was also carried out by feeding experiments with [1-C-13]-, [2-C-13]-, and [1,2-C-13(2)]sodium acetate. The labeling pattern was determined by C-13 NMR including 2D INADEQUATE experiments, which allowed us to elucidate that the chromophore of 1 is derived from 14 acetate. followed by the loss of one carbon atom.