A specialist antigen storage compartment in dendritic cells to sustain cross-presentation.
A specialist antigen storage compartment in dendritic cells to sustain cross-presentation.
复制标题
树突状细胞中的专门抗原储存室，用于维持交叉呈递。
作者：
Cerovic V
树突状细胞 (DC) 在诱导、塑造和维持适应性免疫反应中发挥着关键作用。 DC 作为专业的抗原呈递细胞，能够独特地启动初始 T 细胞的分化。 DC 存在于身体的所有组织中，收集抗原并转运至局部引流淋巴结，并呈递给在血液和淋巴器官之间循环的极其多样化的 T 细胞库。至关重要的是，DC 能够整合来自组织环境的信号并指导适当 T 细胞反应的发展。因此，DC 代表了先天免疫刺激的感知和适应性免疫反应启动之间的关键联系[1]，以及将抗原从外周转运到诱导淋巴区的手段。由于其在免疫反应调节中的核心作用，DC 代表了免疫治疗开发的一个非常有前途的靶点。例如，在对抗传染病时，树突状细胞疫苗接种能够促进疫苗的免疫原性增加，特别是与其他疗法结合使用时[2]。相反，树突状细胞的功能可塑性也可以抑制特定的有害免疫反应。利用 DC 的耐受潜力可以为治疗炎症性疾病、自身免疫或过敏开辟新的治疗方法 [3, 4]。因此，研究和理解 DC 生物学的努力仍然处于医学、免疫学和传染病研究的前沿。
Dendritic cells (DCs) play a key role in inducing, shaping and maintaining adaptive immune responses. DCs act as professional antigen-presenting cells, uniquely able to prime the differentiation of naive T cells. DCs reside in all tissues of the body, collecting antigen for transport to the local draining lymph nodes and for presentation to a hugely diverse repertoire of T cells that recirculate between the blood and lymphoid organs. Crucially, DCs are capable of integrating signals from the tissue environment and instructing the development of appropriate T-c ell responses. Thus, DCs represent a key link between the sensing of innate immune stimuli and the initiation of adaptive immune responses [1], as well as a means of transporting antigen from the periphery to inductive lymphoid compartments.Due to their central role in the regulation of immune responses, DCs represent a highly promising target for the development of immunological therapies. For example, in the fight against infectious disease, dendritic cell vaccination is capable of promoting increased immunogenicity of vaccines, especially in combination with other therapies [2]. Conversely, the functional plasticity of DCs also allows for the suppression of specific deleterious immune responses. Harnessing the tolerogenic potential of DCs can open up new therapeutic approaches for the treatment of inflammatory disorders, autoimmunity or allergy [3, 4]. Thus, efforts to study and understand DC biology remain at the forefront of medical, immunological and infectious disease research.