Highly enantioselective insertion of carbenoids into o-h bonds of phenols:: An efficient approach to chiral α-aryloxycarboxylic esters
Highly enantioselective insertion of carbenoids into o-h bonds of phenols:: An efficient approach to chiral α-aryloxycarboxylic esters
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DOI：
10.1021/ja074729k
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发表时间：
2007-10-24
影响因子：
15
通讯作者：
Zhou, Qi-Lin
中科院分区：
文献类型：
--
作者：
Chen, Chao;Zhu, Shou-Fei;Zhou, Qi-Lin
利用手性螺环双恶唑啉配体实现了铜催化的不对称类卡宾插入酚类的O-H键，高产率地合成了α-芳氧基丙酸酯和相应的丙酸类化合物。
A highly efficient copper-catalyzed asymmetric carbenoid insertion into O-H bonds of phenols has been realized by using chiral spiro bisoxazoline ligands, affording alpha-aryloxypropionates and the related propionic acids in high yields with excellent enantiomeric excesses.