Sonochemically produced fluorocarbon microspheres: a new class of magnetic resonance imaging agent.
Sonochemically produced fluorocarbon microspheres: a new class of magnetic resonance imaging agent.
复制标题
声化学生产的碳氟微球：一种新型磁共振成像剂。
DOI：
10.1002/jmri.1880060417
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Suslick,KS
中科院分区：
文献类型：
--
作者：
Webb,AG;Wong,M;Kolbeck,KJ;Magin,R;Suslick,KS
With the intent of increasing the signal‐to‐noise ratio (SNR) of fluorine magnetic resonance imaging and enabling new applications, we have developed a novel class of agents based on protein encapsulation of fluorocarbons. Microspheres formed by high‐intensity ultrasound have a gaussian size distribution with an average diameter of 2.5 μm. As with conventional emulsions, these microspheres target the reticuloendothelial system. However, our sonochemically produced microspheres, because of a high encapsulation efficiency, show increases in the SNR of up to 300% compared to commercially available emulsions. We also demonstrate an increase in the circulation life‐time of the microspheres within the bloodstream by more than 30‐fold with a chemical modification of the outer surface of the microsphere. Finally, by encapsulating mixtures of fluorocarbons that undergo solid/liquid phase transitions, we can map temperature in the reticuloendothelial system, with signal changes of approximately 20‐fold over a 5°C range.
