GC-MS and GC-IRD studies on brominated dimethoxyamphetamines: regioisomers related to 4-Br-2,5-DMA (DOB).
GC-MS and GC-IRD studies on brominated dimethoxyamphetamines: regioisomers related to 4-Br-2,5-DMA (DOB).
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溴化二甲氧基苯丙胺的 GC-MS 和 GC-IRD 研究：与 4-Br-2,5-DMA (DOB) 相关的区域异构体。
DOI：
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发表时间：
2012
影响因子：
2.9
通讯作者：
C. R. Clark
中科院分区：
文献类型：
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作者：
H. Maher;T. Awad;T. Awad;J. Deruiter;C. R. Clark
一系列区域异构体的溴甲氧基苯丙胺具有与受控药物4-溴-2，5-二甲氧基苯丙胺(4-溴-2，5-二甲氧基苯丙胺；道布)基本相同的质谱图；它们的分子量均为274，电子电离质谱图中的主要碎片离子位于m/z44和m/z230/232。合成了三氟乙酰、五氟丙酰基和七氟丁基伯胺类化合物，并用气相色谱-质谱仪(GC-MS)对其进行了表征。这些衍生物的质谱图没有显示出独特的碎片离子，可用于个别异构体的特定鉴定。然而，根据基峰的不同，质谱图确实可以将化合物分为三类。气相色谱-红外检测(GC-IRD)为从参与研究的其他区域异构体中鉴定设计药物4-溴-2，5-二甲氧基苯丙胺提供了直接的确证数据。在100%二甲基聚硅氧烷固定相(RTX-1)和50%苯基-50%甲基聚硅氧烷固定相(RXi-50)等非极性固定相上成功地拆分了六种溴甲氧基苯丙胺的全氟酰化衍生物。
A series of regioisomeric bromodimethoxyamphetamines have mass spectra essentially equivalent to the controlled drug substance 4-Br-2,5-dimethoxyamphetamine (4-Br-2,5-DMA; DOB); all have molecular weight of 274 and major fragment ions in their electron ionization mass spectra at m/z 44 and m/z 230/232. The trifluoroacetyl, pentafluoropropionyl and heptafluorobutryl derivatives of the primary regioisomeric amines were prepared and evaluated in gas chromatography-mass spectrometry (GC-MS) studies. The mass spectra for these derivatives did not show unique fragment ions for specific identification of individual isomers. However, the mass spectra do serve to divide the compounds into three groups, depending on their base peak. Gas chromatography with infrared detection (GC-IRD) provides direct confirmatory data for the identification of the designer drug 4-bromo-2,5-dimethoxyamphetamine from the other regioisomers involved in the study. The perfluoroacylated derivatives of the six regioisomeric bromodimethoxyamphetamines were successfully resolved on non-polar stationary phases such as a 100% dimethylpolysiloxane stationary phase (Rtx-1) and 50% phenyl - 50% methyl polysiloxane (Rxi-50).