Occupational diesel exhaust exposure as a risk factor for chronic obstructive pulmonary disease.
Occupational diesel exhaust exposure as a risk factor for chronic obstructive pulmonary disease.
复制标题
DOI：
10.1097/mcp.0b013e32834f0eaa
复制
发表时间：
2012-03
影响因子：
3.3
通讯作者：
Laden F
中科院分区：
文献类型：
--
作者：
Hart JE;Eisen EA;Laden F
慢性阻塞性肺病（COPD）是全球发病率和死亡率的主要来源。虽然吸烟是COPD的主要原因，但职业暴露已成为一个重要的风险因素，特别是在非吸烟者中。在这篇综述中，我们评估了COPD与特定职业暴露（柴油废气）相关性的文献状况。大量文献将一般职业暴露于粉尘和烟雾与COPD风险增加联系起来，特别是在非吸烟者中。然而，很少有研究明确研究了职业性柴油废气暴露对COPD风险的作用。最近的研究结果表明，职业性柴油暴露与COPD风险增加有关，直接研究职业性柴油废气对COPD风险影响的现有文献很少，但确实表明，暴露增加与风险增加有关。需要更多的研究，更先进的暴露指标，以充分阐明这种关联。
Chronic obstructive pulmonary disease (COPD) is a major source of morbidity and mortality worldwide. Although cigarette smoking is the major cause of COPD, occupational exposures have emerged as an important risk factor, especially in nonsmokers. In this review we assess the state of the literature on the association of COPD with a specific occupational exposure, diesel exhaust. A large body of literature links general occupational exposures to dust and fumes with an increased risk of COPD, particularly in nonsmokers. Few studies, however, have explicitly examined the role of occupational diesel exhaust exposures to COPD risk. Suggestive recent findings link occupational diesel exposures to an increased risk of COPD, The available literature directly examining the effects of occupational diesel exhaust on risk of COPD is quite small, but does suggest that increasing exposures are associated with increasing risk. Additional research, with more advanced exposure metrics is needed to fully elucidate this association.