B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster.
B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster.
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DOI：
10.17912/micropub.biology.000359
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发表时间：
2021-01-18
影响因子：
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通讯作者：
Kagey JD
中科院分区：
文献类型：
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作者：
Vrailas-Mortimer AD;Aggarwal N;Ahmed NN;Alberts IM;Alhawasli M;Aljerdi IA;Allen BM;Alnajar AM;Anderson MA;Armstong R;Avery CC;Avila EJ;Baker TN;Basardeh S;Bates NA;Beidas FN;Bosler AC;Brewer DM;Buenaventura RS;Burrell NJ;Cabrera-Lopez AP;Cervantes-Gonzalez AB;Cezar RP;Coronel J;Croslyn C;Damery KR;Diaz-Alavez L;Dixit NP;Duarte DL;Emke AR;English K;Eshun AA;Esterly SR;Estrada AJ;Feng M;Freund MM;Garcia N;Ghotra CS;Ghyasi H;Hale CS;Hulsman L;Jamerson L;Jones AK;Kuczynski M;Lacey-Kennedy TN;Lee MJ;Mahjoub T;Mersinger MC;Muckerheide AD;Myers DW;Nielsen K;Nosowicz PJ;Nunez JA;Ortiz AC;Patel TT;Perry NN;Poser WSA;Puga DM;Quam C;Quintana-Lopez P;Rennerfeldt P;Reyes NM;Rines IG;Roberts C;Robinson DB;Rossa KM;Ruhlmann GJ;Schmidt J;Sherwood JR;Shonoda DH;Soellner H;Torrez JC;Velide M;Weinzapfel Z;Ward AC;Bieser KL;Merkle JA;Stamm JC;Tillett RL;Kagey JD
遗传筛选已被用于鉴定参与不同生物过程调节的基因。我们确定了生长突变体的Flp/FRT屏幕上使用果蝇的眼睛，以确定有条件的调节细胞生长和细胞分裂。从该筛选中鉴定出的一种突变体B.2.16由本科遗传学实验室的研究人员绘制并表征，作为Fly-CURE的一部分。我们发现B.2.16是Dark 82嵌合眼表型的非致死性遗传修饰剂。
Genetic screens have been used to identify genes involved in the regulation of different biological processes. We identified growth mutants in a Flp/FRT screen using the Drosophila melanogaster eye to identify conditional regulators of cell growth and cell division. One mutant identified from this screen, B.2.16, was mapped and characterized by researchers in undergraduate genetics labs as part of the Fly-CURE. We find that B.2.16 is a non-lethal genetic modifier of the Dark82 mosaic eye phenotype.