Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging -: art. no. 041202
Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging -: art. no. 041202
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DOI：
10.1117/1.1992485
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发表时间：
2005-07-01
影响因子：
3.5
通讯作者：
Hoffman, RM
中科院分区：
文献类型：
--
作者：
Hoffman, RM
描述了由荧光蛋白实现的体内癌症生物学的革命。荧光蛋白的高消光系数、量子产率和独特的光谱特性已经被利用，以便在真实的时间内可视化活体动物中癌症的重要方面，包括肿瘤细胞运输、侵袭、转移和血管生成。荧光蛋白能够对内脏器官上的肿瘤进行全身成像。这些多色蛋白质允许对体内生长的癌细胞进行颜色编码，区分不同的细胞类型，包括宿主和肿瘤，具有单细胞分辨率。(C)2005年，由光学仪器工程师学会（Society of Photo-Optical Instrumentation Engineers）主办。
The revolution of in vivo cancer biology enabled by fluorescent proteins is described. The high extinction coefficients, quantum yields, and unique spectral properties of fluorescent proteins have been taken advantage of in order to visualize, in real time, the important aspects of cancer in living animals, including tumor cell trafficking, invasion, metastasis, and angiogenesis. Fluorescent proteins enable whole-body imaging of tumors on internal organs. These multicolored proteins have allowed the color-coding of cancer cells growing in vivo with distinction of different cell types, including host from tumor, with single-cell resolution. (C) 2005 Society of Photo-Optical Instrumentation Engineers.