Plasma miR-30a-5p as an early novel noninvasive diagnostic and prognostic biomarker for lung cancer
Plasma miR-30a-5p as an early novel noninvasive diagnostic and prognostic biomarker for lung cancer
复制标题
DOI：
10.2217/fon-2019-0393
复制
发表时间：
2019-11-01
期刊：
影响因子：
3.3
通讯作者：
Luo, Feng-Ming
中科院分区：
文献类型：
--
作者：
Liang, Ling-Bo;Zhu, Wen-Jun;Luo, Feng-Ming
目的：循环miRNAs在肺癌的诊断和预后中的作用日益受到重视。本研究旨在鉴定和评估血浆miRNA-30 a-5 p作为肺癌诊断和预后的早期非侵入性生物标志物。方法：采用实时荧光定量PCR技术检测血浆中30 a-5 p的表达水平。受试者工作特征分析和曲线下面积用于区分恶性肿瘤和良性肿瘤以及健康对照。Kaplan-Meier曲线和考克斯回归分析用于确定生存和预后。结果如下：我们的研究结果表明，血浆中miRNA-30 a-5 p的水平可能是一个相当大的早期新的非侵入性诊断和预后的肺癌生物标志物。结论：必须进行前瞻性研究，以确认这一新的早期非侵入性诊断和预后的肺癌生物标志物。
Aim: Circulation miRNAs have become increasingly appreciated in the diagnosis and prognosis of lung cancer. This study aims to identify and evaluate plasma miRNA-30a-5p as an early noninvasive biomarker for the diagnosis and prognosis of lung cancer. Pateints & methods: Expression levels of plasma miRNA 30a-5p were measured by quantitative real-time PCR. Receiver operating characteristic analysis and area under the curve were used to differentiate malignant from benign tumors and from healthy controls. Kaplan-Meier curves and Cox regression were used to determine survival and prognosis. Results: Our results suggest that the level of miRNA-30a-5p in plasma might be a considerable early novel noninvasive diagnostic and prognostic biomarker for lung cancer. Conclusion: Prospective studies must be performed to confirm this new early novel noninvasive diagnostic and prognostic biomarker for lung cancer.