Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study.
Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study.
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DOI：
10.1371/journal.pone.0147894
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Robinson JG
中科院分区：
文献类型：
--
作者：
Harris WS;Luo J;Pottala JV;Margolis KL;Espeland MA;Robinson JG
饮食和/或循环中脂肪酸水平与2型糖尿病发生之间的关系尚不清楚。已报道了与海洋ω-3脂肪酸和亚油酸以及与脂肪酸去饱和酶活性δ-5去饱和酶（D5D比率）的标志物的保护性关联，与饱和脂肪酸和D6D比率具有不利关系。确定红细胞（RBC）脂肪酸分布与2型糖尿病发病之间的关系。前瞻性观察性队列研究嵌套在妇女健康倡议记忆研究。一般民众。绝经后妇女。自我报告的2型糖尿病事件。在6379名绝经后妇女中，有703例新的2型糖尿病病例超过11年的随访。在完全校正的模型中，基线RBC D5D比值与2型糖尿病发病率呈负相关[风险比（HR）0.88，95%置信区间（CI）0.81 - 0.95）/1 SD增加。同样，基线RBC D6D比值和棕榈酸与2型糖尿病事件直接相关（分别为HR 1.14，95% CI 1.04 - 1.25; HR 1.24，95% CI 1.14 - 1.35）。在随访的前两年，排除事件病例后，这些关系均未发生实质性改变。与二十碳五烯酸、二十二碳六烯酸和亚油酸无明显关系。这项研究无法确定脂肪酸去饱和酶活性或棕榈酸水平的改变是否与2型糖尿病的发生有因果关系，但我们的研究结果表明，红细胞膜中某些脂肪酸的比例与2型糖尿病的风险有关。
The relations between dietary and/or circulating levels of fatty acids and the development of type 2 diabetes is unclear. Protective associations with the marine omega-3 fatty acids and linoleic acid, and with a marker of fatty acid desaturase activity delta-5 desaturase (D5D ratio) have been reported, as have adverse relations with saturated fatty acids and D6D ratio. To determine the associations between red blood cell (RBC) fatty acid distributions and incident type 2 diabetes. Prospective observational cohort study nested in the Women’s Health Initiative Memory Study. General population. Postmenopausal women. Self-reported incident type 2 diabetes. There were 703 new cases of type 2 diabetes over 11 years of follow up among 6379 postmenopausal women. In the fully adjusted models, baseline RBC D5D ratio was inversely associated with incident type 2 diabetes [Hazard Ratio (HR) 0.88, 95% confidence interval (CI) 0.81–0.95) per 1 SD increase. Similarly, baseline RBC D6D ratio and palmitic acid were directly associated with incident type 2 diabetes (HR 1.14, 95% CI 1.04–1.25; and HR 1.24, 95% CI 1.14–1.35, respectively). None of these relations were materially altered by excluding incident cases in the first two years of follow-up. There were no significant relations with eicosapentaenoic, docosahexaenoic or linoleic acids. Whether altered fatty acid desaturase activities or palmitic acid levels are causally related to the development of type 2 diabetes cannot be determined from this study, but our findings suggest that proportions of certain fatty acids in RBC membranes are associated with risk for type 2 diabetes.