Flash nanoprecipitation of hafnia nanoparticle computed tomography contrast agent
Flash nanoprecipitation of hafnia nanoparticle computed tomography contrast agent
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DOI：
10.1007/s11051-023-05763-w
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发表时间：
2023-05
影响因子：
2.5
通讯作者：
Sitong Liu;Matthew Po;Anahita Heshmat;Evan Anguish;J. Andrew;Carlos M. Rinaldi‐Ramos
中科院分区：
文献类型：
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作者：
Sitong Liu;Matthew Po;Anahita Heshmat;Evan Anguish;J. Andrew;Carlos M. Rinaldi‐Ramos
氧化铪纳米粒子由于其高的X射线衰减和低的成本而作为计算机断层扫描（CT）造影剂的应用近来引起了人们的注意。在这里，我们采用快速纳米沉淀法（FNP）配制纳米氧化物纳米簇（HNC）的沉淀的单个纳米氧化物纳米颗粒和聚乳酸均聚物和嵌段共聚物聚乳酸-b-聚乙二醇（PLA-b-PEG）的外层涂层的核心组成。HNC可以使用简单的3D打印FNP混合器以100-300 nm范围内的受控流体动力学尺寸生产。在临床前小动物扫描仪和临床扫描仪中评价HNC的CT性能。在两种系统中，HNC显示的对比度比临床使用的市售碘化分子造影剂Omnipaque高约1.5倍。
Hafnium oxide (hafnia) nanoparticles have recently attracted attention for their application as computed tomography (CT) contrast agents due to their high X-ray attenuation and low cost. Here we employ flash nanoprecipitation (FNP) to formulate hafnia nanoclusters (HNCs) consisting of a core of precipitated individual hafnia nanoparticles and polylactic acid homopolymer and an outer coating of the block copolymer polylactic acid-b-polyethylene glycol (PLA-b-PEG). The HNCs can be produced with controlled hydrodynamic size in the range of 100–300 nm using a simple 3D-printed FNP mixer. The CT performance of the HNCs was evaluated in a pre-clinical small animal scanner and in a clinical scanner. In both systems the HNCs displayed ~1.5× greater contrast compared to the commercial iodinated molecular contrast agent Omnipaque used clinically.