Investigative pathology: leading the post-genomic revolution
Investigative pathology: leading the post-genomic revolution
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DOI：
10.1038/labinvest.2011.147
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发表时间：
2012-01-01
影响因子：
5
通讯作者：
Loda, Massimo
中科院分区：
文献类型：
--
作者：
Berman, David M.;Bosenberg, Marcus W.;Loda, Massimo
人类基因组计划的完成和过去十年中基于基因组的技术的发展为个性化医疗的新时代奠定了基础。无论如何，经过分子训练的病理学家应该领导这场革命。分子病理学家非常适合这项工作，他们具有罕见的能力，可以将基因组工具与独特的诊断技能和基于组织的病理学技术结合起来，用于人类疾病的综合诊断。然而，由于过时的培训方法和一些传统病理学家不愿接受新技术，拥有基因组研究专业知识的病理学家数量仍然相对较低。此外，由于初露头角的病理学家可能不欣赏他们可以选择的大量工作，他们最终往往选择几乎完全专注于常规诊断的工作，而不是分子病理学的新前沿。这项评论呼吁进行旨在纠正这些令人不安的趋势的变革，以确保病理学在后基因组时代继续指导患者护理。实验室调查（2012）92，4-8; doi：10.1038/labinvest.2011.147; 2011年10月10日在线发表
The completion of the Human Genome Project and the development of genome-based technologies over the past decade have set the stage for a new era of personalized medicine. By all rights, molecularly trained investigative pathologists should be leading this revolution. Singularly well suited for this work, molecular pathologists have the rare ability to wed genomic tools with unique diagnostic skills and tissue-based pathology techniques for integrated diagnosis of human disease. However, the number of pathologists with expertise in genome-based research has remained relatively low due to outdated training methods and a reluctance among some traditional pathologists to embrace new technologies. Moreover, because budding pathologists may not appreciate the vast selection of jobs available to them, they often end up choosing jobs that focus almost entirely on routine diagnosis rather than new frontiers in molecular pathology. This review calls for changes aimed at rectifying these troubling trends to ensure that pathology continues to guide patient care in a post-genomic era. Laboratory Investigation (2012) 92, 4-8; doi: 10.1038/labinvest.2011.147; published online 10 October 2011