Brain-derived neutrophic factor in adolescents smoking waterpipe: The Irbid TRY
Brain-derived neutrophic factor in adolescents smoking waterpipe: The Irbid TRY
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DOI：
10.1016/j.ijdevneu.2018.03.007
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发表时间：
2018-06-01
影响因子：
1.8
通讯作者：
Alzoubi, Karem H.
中科院分区：
文献类型：
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作者：
Alomari, Mahmoud A.;Al-Sheyab, Nihaya A.;Alzoubi, Karem H.
背景：脑源性中性营养因子（BDNF）和烟草消费可影响许多身体功能和健康。然而，BDNF与水烟（Wp）吸烟的关系尚不清楚。因此，本研究考察了吸烟与青少年BDNF之间的关系。方法：对195名吸烟学生和288名不吸烟学生的自我报告烟草消费量和血清BDNF进行测定。结果：纳入吸烟Wp、性别、BMI、地理位置的逐步回归分析显示，只有吸烟Wp （p < 0.0001）和性别（p < 0.0001）与血清BDNF相关。此外，ANCOVA还发现，男性吸水烟的BDNF较低，主要影响因素是Wp吸烟（p < 0.0001）和性别（p < 0.0001）。讨论：青少年吸烟者BDNF减少，这可能使青少年易发生系统性的不良健康和行为改变。这些结果将与吸烟有关的负面健康风险扩展到水烟。
Background: Brain-derived neutrophic factor (BDNF) and tobacco consumption can affect many body functions and health. However, the relationship of BDNF with waterpipe (Wp) smoking is unknown. Therefore, the current study examined the relationship between Wp smoking and BDNF in adolescents.Methods: Self-reported tobacco consumption and serum BDNF were determined in 195 waterpipe and 288 nonsmokers in 7th-10th grade students.Results: Stepwise regression that included Wp smoking, gender, BMI, and location, showed that only Wp smoking (p < 0.0001) and gender (p < 0.0001) were related to serum BDNF. In addition, the ANCOVA found a main effect for Wp smoking (p < 0.0001) and gender (p < 0.0001) with lower BDNF in males smoking waterpipe.Discussion: BDNF was diminished in adolescent Wp smokers, which might predispose adolescents for systematic adverse health and behavioral alterations. These results extend the negative health risks associated with cigarette smoking to that of water-pipe tobacco smoking.