Optimization of the epithermal neutron beam for Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor
Optimization of the epithermal neutron beam for Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor
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DOI：
10.1097/00004032-200405002-00013
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发表时间：
2004-05-01
期刊：
影响因子：
2.2
通讯作者：
Holden, NE
中科院分区：
文献类型：
--
作者：
Hu, JP;Reciniello, RN;Holden, NE
超热中子束在针对恶性脑肿瘤患者的硼中子俘获疗法的临床试验中的兴起，已经在布鲁克海文的医疗反应堆进行了五年（决定永久关闭该反应堆），并于 2000 年关闭该反应堆，从而缩短了实施新概念设计以优化该束流的努力，为可能的新 BNCT 协议的兴起做好准备。这里介绍了轮胎概念设计的细节，以产生高度强化和聚焦的中子束，组织中的伽马和中子污染较少，因为它们对其他反应堆设施的潜在适用性。 Alentron-光子耦合蒙特卡罗计算用于预测轮胎通量、电流、热量和轮胎设计产生的吸收剂量。结果以在当时使用的设施中进行的剂量率和通量测量为基准。
The rise of epithermal neutron beam in clinical trials of Boron Neotron Capture Therapy for patients with malignant brain tumors had been carried out for half a decade at the Brookhaven's Medical Reactor The decision to permanently), close this reactor in 2000 cat short the efforts to implement a new conceptual design to opthimize this beam in preparation for rise with possible new, BNCT protocols. Details of tire conceptual design to produce a highly intensified and focused neutron beam with less gamma and neutron contamination in tissues are presented here for their potential applicability to other reactor facilities. Alentron-photon coupled Monte Carlo calculations were used to predict tire flux, current, heating, and absorbed dose produced by tire proposed design. The results were bench-marked by the dose rate and flux measurements taken at the facility then in use.