Short-term modulation of the lesioned language network
Short-term modulation of the lesioned language network
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DOI：
10.7554/elife.54277
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发表时间：
2020-03-17
期刊：
影响因子：
7.7
通讯作者：
Saur, Dorothee
中科院分区：
文献类型：
--
作者：
Hartwigsen, Gesa;Stockert, Anika;Saur, Dorothee
语言是由人脑中的大规模网络维持的。中风常常严重影响功能和网络动力学。然而，大脑补偿损伤的适应性潜力尚不清楚。一个关键的问题是右半球的上调是否适应语言恢复。针对受损大脑短期重组的潜力，我们在脑卒中后患者的左侧颞顶叶病变（IFG）上应用“虚拟病变”，在功能神经影像学之前进行左侧颞顶叶病变。后侧IFG的扰动选择性地延迟语音决定和减少语音活动。个体反应延迟与病变同系物的上调相关，可能反映了代偿。此外，右上纵束的单个束完整性越强，损伤越小。我们的研究结果为受损语言网络可塑性的功能和结构基础以及右半球的代偿作用提供了证据。
Language is sustained by large-scale networks in the human brain. Stroke often severely affects function and network dynamics. However, the adaptive potential of the brain to compensate for lesions is poorly understood. A key question is whether upregulation of the right hemisphere is adaptive for language recovery. Targeting the potential for short-term reorganization in the lesioned brain, we applied 'virtual lesions' over left anterior or posterior inferior frontal gyrus (IFG) in post-stroke patients with left temporo-parietal lesions prior to functional neuroimaging. Perturbation of the posterior IFG selectively delayed phonological decisions and decreased phonological activity. The individual response delay was correlated with the upregulation of the lesion homologue, likely reflecting compensation. Moreover, stronger individual tract integrity of the right superior longitudinal fascicle was associated with lesser disruption. Our results provide evidence for functional and structural underpinnings of plasticity in the lesioned language network, and a compensatory role of the right hemisphere.