THE ROLE OF T-CELL GROWTH STIMULATING FACTORS IN T-CELL TRIGGERING
THE ROLE OF T-CELL GROWTH STIMULATING FACTORS IN T-CELL TRIGGERING
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DOI：
10.1111/j.1600-065x.1980.tb00316.x
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发表时间：
1980-01-01
影响因子：
8.7
通讯作者：
ANDERSSON, J
中科院分区：
文献类型：
--
作者：
GRONVIK, KO;ANDERSSON, J
免疫系统中大多数细胞的反应受到其他细胞和分子的影响。因此，对功能的分析，即给定反应性的可测量结果，经常涉及其他细胞或由其他细胞产生的分子。我们还知道，某些功能谱系的细胞，如b细胞，在表面结构和对调节剂的易感性方面确实会随着分化而改变。最近发展的克隆正常T细胞的技术允许对T细胞刺激中涉及的一些个体参数进行功能分析。本文的目的是描述细胞对T细胞生长刺激因子（TCGF）产生的需求，并确定这些因子在T细胞刺激中的作用。
Most ceils in the imtnune system are influenced in their reactivities by other cells and molecules. Therefore the analysis of functions, ie the measureable result of a given reactivity, frequently involves other cells or molecules produced by other cells. It is also known that cells of a certain functional lineage, eg B-cells, do change with differentiation in terms of surface structures as well as susceptibility to regulatory agents.Recently developed techniques for cloning of normal T cells allows for the functional analysis of some of the individual parameters involved in T cell stimulation. It is the purpose of this paper to describe the cellular requirements for the production of T cell growth stimulating factors (TCGF) and to determine the role of these factors in T cell stimulation.