Effect of acute acoustic stress on anorectal function and sensation in healthy humans
Effect of acute acoustic stress on anorectal function and sensation in healthy humans
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DOI：
10.1111/j.1365-2982.2004.00592.x
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发表时间：
2005-04-01
影响因子：
3.5
通讯作者：
Chey, WD
中科院分区：
文献类型：
--
作者：
Gonlachanvit, S;Rhee, J;Chey, WD
目前关于急性声应激对肛门直肠功能的影响还知之甚少。探讨急性声应激对健康志愿者肛门直肠功能和感觉的影响。10名健康志愿者（7名男性，3名女性，平均年龄34 +/- 3岁）接受了肛门直肠测压，在不同的日子使用恒压器在有和没有急性噪声应激的情况下测试直肠顺应性和感觉。直肠知觉采用限制方案的上升法和5分制李克特量表进行评估。唤醒和焦虑状态进行了评估，使用视觉模拟量表。听觉应激使焦虑评分显著升高（P < 0.05）。与对照组相比，直肠顺应性显著降低（P < 0.000001）。另外，在声刺激下，引起严重尿急感所需的球囊内容积较少（P < 0.05）。声应力对血流动力学参数、肛门括约肌压力、第一感觉阈值、大便感觉或疼痛没有影响。在健康志愿者中，急性声刺激增加焦虑评分，降低直肠顺应性，增强对球囊扩张的严重紧迫感，但不影响肛门括约肌压力。这些结果可能会提供深入了解应激引起的腹泻和粪便紧迫的发病机制。
Little is known about the effects of acute acoustic stress on anorectal function. To determine the effects of acute acoustic stress on anorectal function and sensation in healthy volunteers. Ten healthy volunteers (7 M, 3 F, mean age 34 +/- 3 years) underwent anorectal manometry, testing of rectal compliance and sensation using a barostat with and without acute noise stress on separate days. Rectal perception was assessed using an ascending method of limits protocol and a 5-point Likert scale. Arousal and anxiety status were evaluated using a visual analogue scale. Acoustic stress significantly increased anxiety scores (P < 0.05). Rectal compliance was significantly decreased with acoustic stress compared with control (P < 0.000001). In addition, less intraballoon volume was needed to induce the sensation of severe urgency with acoustic stress (P < 0.05). Acoustic stress had no effect on hemodynamic parameters, anal sphincter pressure, threshold for first sensation, sensation of stool, or pain. Acute acoustic stimulation increased anxiety scores, decreased rectal compliance, and enhanced perception of severe urgency to balloon distention but did not affect anal sphincter pressure in healthy volunteers. These results may offer insight into the pathogenesis of stress-induced diarrhoea and faecal urgency.