Short-latency drinking and increased Na appetite after intracerebral microinjections of NGF in rats
Short-latency drinking and increased Na appetite after intracerebral microinjections of NGF in rats
复制标题
大鼠脑内微量注射 NGF 后短潜伏期饮酒和钠食欲增加
作者：
M. E. Lewis;D. Avrith;J. Fitzsimons
神经生长因子 (NGF) 是一种外周交感神经和感觉神经元的多肽营养因子1,2。大脑中也发现了明显的 NGF3-5 和 NGF 受体 6,7，并且在成年大鼠脑内施用 NGF 会在脑组织中产生显着的生化 8 和形态学 9,10 变化。这些发现与中枢注射 NGF 促进脑损伤行为恢复11,12 的观察结果相结合，表明这种多肽可能在脑功能中发挥重要作用。据观察，脑室内注射高达 2.3 µg NGF 的大鼠会大量饮酒（M.E.L. 和 G. Guroff，未发表的观察结果）。 Perkins 等人 13 报告称，间脑应用结晶 NGF（1-15 µg）会导致严重烦渴。本报告证实了 M.E.L. 的观察结果。和 Guroff，并通过使用 NGF 溶液代替晶体扩展了 Perkins 等人的发现13。它还首次描述了颅内施用 NGF 产生的第二种现象，即对令人厌恶浓度的钠溶液的强烈食欲。
NERVE GROWTH FACTOR (NGF) is a polypeptide trophic factor for peripheral sympathetic and sensory neurones1,2. Apparent NGF3–5 and NGF receptors6,7 have also been identified in the brain, and intracerebral administration of NGF in the adult rat produces marked biochemical8 and morphologica9,10 changes in brain tissue. These findings, taken together with the observations that central injections of NGF facilitate behavioural recovery from brain damage11,12, indicate that this polypeptide may have an important role in brain function. It has been observed that rats given intraventricular injections of up to 2.3 µg NGF drink copiously (M.E.L. and G. Guroff, unpublished observations). Perkins et al.13 reported that diencephalic application of crystalline NGF (1–15 µg) resulted in an intense polydipsia. The present report confirms the observations of M.E.L. and Guroff, and extends the findings of Perkins et al.13 by using solutions of NGF instead of crystals. It also describes for the first time a second phenomenon produced by intracranial administration of NGF, namely an intense appetite for aversive concentrations of sodium solutions.