Towards the identification of biomarkers of transplantation tolerance
Towards the identification of biomarkers of transplantation tolerance
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DOI：
10.1038/nri2568
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发表时间：
2009-07-01
影响因子：
100.3
通讯作者：
Lechler, Robert I.
中科院分区：
文献类型：
--
作者：
Turka, Laurence A.;Lechler, Robert I.
虽然移植已经是一个标准的医疗实践了几十年，免疫抑制药物的使用和长期移植物存活率差的显着发病率仍然是该领域的重要限制。实现对移植器官的耐受性应该可以解决这两个问题，但这一直是一个难以捉摸的目标。人类免疫工具箱的最新进展重新点燃了研究少数移植受体的兴趣，这些受体随着时间的推移对其移植物产生了耐受性。移植耐受生物标志物的发展有望改善器官移植受者的护理，提供替代终点的耐受诱导策略，并促进我们对自身和外来抗原的人类免疫反应的理解。
Although transplantation has been a standard medical practice for decades, the marked morbidity from the use of immunosuppressive drugs and poor long-term graft survival remain important limitations in the field. Achieving tolerance to transplanted organs should solve both problems, but has been an elusive goal. Recent advances in the human immunological toolbox have rekindled interest in studying the small number of transplant recipients who become tolerant to their grafts over time. The development of biomarkers of transplantation tolerance holds promise to improve the care of organ allograft recipients, to provide surrogate end points of tolerance induction strategies and to advance our understanding of the human immune response to both self and foreign antigens.