A Processable Shape Memory Polymer System for Biomedical Applications.
A Processable Shape Memory Polymer System for Biomedical Applications.
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DOI：
10.1002/adhm.201500156
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发表时间：
2015-06-24
影响因子：
10
通讯作者：
Maitland DJ
中科院分区：
文献类型：
--
作者：
Hearon K;Wierzbicki MA;Nash LD;Landsman TL;Laramy C;Lonnecker AT;Gibbons MC;Ur S;Cardinal KO;Wilson TS;Wooley KL;Maitland DJ
聚氨酯形状记忆聚合物（SMP）与可调的热机械性能和先进的加工能力已被合成，其特征在于，并在设计中实施的微致动器医疗设备原型。操纵低分子量脂肪族热塑性聚氨酯SMP中的玻璃化转变温度（Tg）和交联密度的能力使用采用UV催化的硫醇-烯“点击”反应以实现聚合后交联的合成方法来证明。合成了含有不同C=C官能化的PU，将溶液与多硫醇交联剂和光引发剂共混并进行UV照射，并报道了合成参数的数量对交联密度的影响。热机械性能是高度可调的，包括在30和105°C之间可定制的玻璃化转变和在0.4和20 MPa之间可定制的橡胶模量。这种新的SMP体系对许多配方都表现出高韧性，特别是在低交联密度材料的情况下，其韧性在选定的应变温度下超过90 MJ/m3。为了证明这种新的SMP系统的先进的处理能力和合成的多功能性，制造了用于血管内器械微创输送的激光致动SMP微夹持器装置，显示出1.43 ± 0.37 N的平均夹持力，并在模拟生理条件下在体外实验装置中成功部署。报道了一种用于生物医学器件应用的新型平台形状记忆聚合物系统，其表现出独特的可调、高性能机械属性与先进的加工能力和良好的生物相容性的结合。采用后聚合交联合成方法，结合聚氨酯和硫醇烯合成工艺，并制造微致动器医疗设备原型，以证明这种新的SMP系统的处理能力。
Polyurethane shape memory polymers (SMPs) with tunable thermomechanical properties and advanced processing capabilities have been synthesized, characterized, and implemented in the design of a microactuator medical device prototype. The ability to manipulate glass transition temperature (Tg) and crosslink density in low-molecular weight aliphatic thermoplastic polyurethane SMPs is demonstrated using a synthetic approach that employs UV catalyzed thiol-ene “click” reactions to achieve post-polymerization crosslinking. PUs containing varying C=C functionalization are synthesized, solution blended with polythiol crosslinking agents and photoinitiator and subjected to UV irradiation, and the effects of number of synthetic parameters on crosslink density are reported. Thermomechanical properties are highly tunable, including glass transitions tailorable between 30 and 105°C and rubbery moduli tailorable between 0.4 and 20 MPa. This new SMP system exhibits high toughness for many formulations, especially in the case of low crosslink density materials, for which toughness exceeds 90 MJ/m3 at select straining temperatures. To demonstrate the advanced processing capability and synthetic versatility of this new SMP system, a laser-actuated SMP microgripper device for minimally invasive delivery of endovascular devices is fabricated, shown to exhibit an average gripping force of 1.43 ± 0.37 N and successfully deployed in an in vitro experimental setup under simulated physiological conditions. A new platform shape memory polymer system for biomedical device applications is reported that exhibits a unique blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes, and a microactuator medical device prototype is fabricated to demonstrate the processing capability of this new SMP system.