An Opportunity to Increase Collaborative Science in Fetal, Infant, and Toddler Neuroimaging.
An Opportunity to Increase Collaborative Science in Fetal, Infant, and Toddler Neuroimaging.
复制标题
增加胎儿、婴儿和幼儿神经影像学协作科学的机会。
DOI：
10.1016/j.biopsych.2022.07.005
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发表时间：
2023
影响因子：
10.6
通讯作者：
Vaughn,KellyA
中科院分区：
文献类型：
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作者：
Fetal,Infant,andToddlerNeuroimagingGroup;Korom,Marta;CatalinaCamacho,M;Ford,Aiden;Taha,Hana;Scheinost,Dustin;Spann,Marisa;Vaughn,KellyA
胎儿，婴儿和幼儿（FIT）神经成像研究领域-包括磁共振成像（MRI），脑电图（EEG），脑磁图和功能性近红外光谱等-提供了对早期大脑发育的开创性见解，并在过去20年中越来越受欢迎。在更广泛的神经影像学研究中，多地点合作项目、数据共享和开源代码越来越成为常态，促进了大数据、共识标准以及快速的知识转移和开发。鉴于上述好处，沿着最近资助机构支持多站点和多模式FIT神经影像学研究的举措，FIT领域现在有机会建立可持续的，协作的和开放的科学实践。通过结合数据和资源，我们可以解决FIT领域最紧迫的问题，包括小效应量，可复制性问题，可推广性问题，以及缺乏数据收集，处理和分析的领域标准。因此，本文的目的是强调阻碍这些努力的一些潜在障碍，并讨论新兴的解决方案，这些解决方案有可能彻底改变我们如何共同研究生命早期发育中的大脑。虽然FIT的发育仅涵盖约3年的时间，从妊娠到幼儿后期，它代表了生命周期中大脑和行为成熟的最快速和动态的时期（1）。婴儿心理健康工作表明，这个令人难以置信的可塑期是精神病风险的前因在神经系统中实例化的时候，在正式诊断之前。因此，绘制健康的大脑发育图以支持基础和转化科学目标将需要在此期间采取密集采样和灵活的措施。
The field of fetal, infant, and toddler (FIT) neuroimaging research—including magnetic resonance imaging (MRI), electroencephalography (EEG), magnetoencephalography, and functional near-infrared spectroscopy, among others—offers pioneering insights into early brain development and has grown in popularity over the past 2 decades. In broader neuroimaging research, multisite collaborative projects, data sharing, and open-source code have increasingly become the norm, fostering big data, consensus standards, and rapid knowledge transfer and development. Given the aforementioned benefits, along with recent initiatives from funding agencies to support multisite and multimodal FIT neuroimaging studies, the FIT field now has the opportunity to establish sustainable, collaborative, and open science practices. By combining data and resources, we can tackle the most pressing issues of the FIT field, including small effect sizes, replicability problems, generalizability issues, and the lack of field standards for data collection, processing, and analysis—together. Thus, the goals of this commentary are to highlight some of the potential barriers that have waylaid these efforts and to discuss the emerging solutions that have the potential to revolutionize how we work together to study the developing brain early in life.Although FIT development encompasses only about 3 years’ time, from gestation to late toddlerhood, it represents the most rapid and dynamic period of brain and behavior maturation within the lifespan (1). Infant mental health work suggests that this incredibly plastic period is when antecedents of psychiatric risk are instantiated in neural systems, before a formal diagnosis can be made. Therefore, charting healthy brain development in support of basic and translational science goals will require densely sampled and flexible measures across this period.