The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches.
The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches.
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DOI：
10.1016/j.xcrm.2023.101360
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发表时间：
2024-01-16
期刊：
影响因子：
--
通讯作者：
Liu GY
中科院分区：
文献类型：
--
作者：
Caldera JR;Tsai CM;Trieu D;Gonzalez C;Hajam IA;Du X;Lin B;Liu GY
The failure of the Staphylococcus aureus (SA) IsdB vaccine trial can be explained by the recall of non-protective immune imprints from prior SA exposure. Here, we investigate natural human SA humoral imprints to understand their broader impact on SA immunizations. We show that antibody responses against SA cell-wall-associated antigens (CWAs) are non-opsonic, while antibodies against SA toxins are neutralizing. Importantly, the protective characteristics of the antibody imprints accurately predict the failure of corresponding vaccines against CWAs and support vaccination against toxins. In passive immunization platforms, natural anti-SA human antibodies reduce the efficacy of the human monoclonal antibodies suvratoxumab and tefibazumab, consistent with the results of their respective clinical trials. Strikingly, in the absence of specific humoral memory responses, active immunizations are efficacious in both naive and SA-experienced mice. Overall, our study points to a practical and predictive approach to evaluate and develop SA vaccines based on pre-existing humoral imprint characteristics. The target antigen and antibody titer predict outcome of S. aureus vaccines in mice Pre-existing human antibodies limit efficacy of anti-S. aureus monoclonal antibodies Interference from imprints is avoided by vaccinating against subdominant antigens There has been no successful vaccine against S. aureus after approximately 30 human trials. Humans are exposed to S. aureus early on in life. Caldera et al. show that the type of antigen target and the titer of pre-existing antibodies can predict the outcome of staphylococcal vaccines in pathogen-exposed mice.
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影响因子：
11.8
作者：
Fritz, Stephanie A.;Tiemann, Kristin M.;Hunstad, David A.
通讯作者：
Hunstad, David A.
金黄色葡萄球菌蛋白A A破坏了由长寿命的浆细胞介导的免疫力。
DOI：
10.4049/jimmunol.1600093
发表时间：
2017-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Keener AB;Thurlow LT;Kang S;Spidale NA;Clarke SH;Cunnion KM;Tisch R;Richardson AR;Vilen BJ
通讯作者：
Vilen BJ
影响因子：
4.8
作者：
Inoue M;Yonemura T;Baber J;Shoji Y;Aizawa M;Cooper D;Eiden J;Gruber WC;Jansen KU;Anderson AS;Gurtman A
通讯作者：
Gurtman A
影响因子：
30.3
作者：
Fiege JK;Block KE;Pierson MJ;Nanda H;Shepherd FK;Mickelson CK;Stolley JM;Matchett WE;Wijeyesinghe S;Meyerholz DK;Vezys V;Shen SS;Hamilton SE;Masopust D;Langlois RA
通讯作者：
Langlois RA
DOI：
10.1073/pnas.2003621117
发表时间：
2020-09-15
影响因子：
11.1
作者：
Chen X;Shi M;Tong X;Kim HK;Wang LX;Schneewind O;Missiakas D
通讯作者：
Missiakas D