Sinoaortic denervation does not increase cardiovascular/endocrine responses to stress.
Sinoaortic denervation does not increase cardiovascular/endocrine responses to stress.
复制标题
主动脉去神经术不会增加心血管/内分泌对压力的反应。
DOI：
10.1159/000126301
复制
发表时间：
1992
影响因子：
4.1
通讯作者：
Morris,M
中科院分区：
文献类型：
--
作者：
Callahan,MF;daRocha,MJ;Morris,M
据报道，窦主动脉压力感受器去神经可产生过度的中枢性心血管和内分泌反应。我们研究了雄性SD大鼠去窦弓神经支配（SAD）对两种急性应激源（足电击和制动）的心血管和内分泌反应的影响。测量的参数是平均动脉压（MAP）、心率（HR）和血浆催产素（OT）和加压素（VP）水平。SAD组的基线MAP升高（> 25 mm Hg），足电击应激使两组的动脉压升高幅度相等。这种压力导致心动过速和血浆OT增加，SAD组倾向于表现出迟钝的反应。固定增加了心率，但没有引起MAP变化，组间也没有显着差异。这种形式的压力也增加了血浆OT，SAD组再次显示出减弱的反应。血浆VP没有显着改变，无论是应激。这些研究的结果表明，SAD并不均匀地增加心血管和内分泌反应的所有压力源或中枢来源的刺激。这些结果还表明，缺乏增加血浆VP是不相关的压力感受器介导的抑制分泌压力条件下。
Sinoaortic baroreceptor denervation is reported to produce exaggerated centrally derived cardiovascular and endocrine responses. We examined the effect of sinoaortic denervation (SAD) on the cardiovascular and endocrine responses to two acute stressors, footshock and immobilization, in male Sprague-Dawley rats. Parameters measured were mean arterial pressure (MAP), heart rate (HR) and plasma levels of oxytocin (OT) and vasopressin (VP). Baseline MAP was elevated in the SAD group (≈25 mm Hg) and footshock stress increased arterial pressure equivalently in both groups. This stress caused tachycardia and increased plasma OT, with a tendency for the SAD group to show blunted responses. Immobilization increased HR but caused no change in MAP and no significant difference between the groups. This form of stress also increased plasma OT, and again the SAD group showed a diminished response. Plasma VP was not significantly altered by either stressor. The results of these studies indicate that SAD does not uniformly increase the cardiovascular and endocrine responses to all stressors or centrally derived stimuli. These results also suggest that the lack of an increase in plasma VP is not related to baroreceptor-mediated inhibition of secretion under stressful conditions.