Associations between physical fitness and HbA1c in type 2 diabetes mellitus
Associations between physical fitness and HbA1c in type 2 diabetes mellitus
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DOI：
10.1007/s00125-010-1941-3
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发表时间：
2011-01-01
期刊：
影响因子：
8.2
通讯作者：
Kenny, G. P.
中科院分区：
文献类型：
--
作者：
Larose, J.;Sigal, R. J.;Kenny, G. P.
目的/假设 对于 2 型糖尿病患者，运动可改善血糖控制（如 HbA(1c) 所反映）和身体健康，但尚不清楚这些运动引起的改善在多大程度上相互关联。我们假设 HbA(1c) 的降低与：(1) 进行有氧训练或阻力训练的患者的有氧适能和力量分别增加有关； (2) 进行有氧训练和阻力训练的患者力量和有氧适能的变化。方法 我们将 251 名 2 型糖尿病患者随机分配到有氧训练、阻力训练或有氧加阻力训练组，或静坐对照组。在基线和 6 个月时测量峰值耗氧量（V (V) 超过 dotO(2peak)）、工作负荷、跑步机时间和最大跑步机运动测试的通气阈值。肌肉力量的测量是在腿举、卧推和坐式划船练习中可举起八次的最大重量。 结果 通过有氧训练，发现 (V)over dotO(2peak) (p = 0.040) 和工作量 (p = 0.022) 的变化与 HbA(1c) 的变化之间存在显着关联。通过联合训练，(V)相对于 dotO(2peak) (p = 0.008)、工作量 (p = 0.034) 和通气阈值 (p = 0.003) 的改善与 HbA1c 的变化显着相关。坐式划船力量的增加 (p = 0.006) 和大腿中部肌肉横截面积的增加 (p = 0.030) 与阻力运动后 HbA(1c) 的变化显着相关，而进行有氧加阻力运动的参与者的肌肉横截面积的增加和 HbA(1c) 之间的关联 (p = 0.059) 具有临界意义。 结论/解释 变化之间似乎存在关联健身和 HbA(1c)。有氧训练对心肺健康的改善可能比力量的改善更能预测 HbA(1c) 的变化。
Aim/hypothesis In people with type 2 diabetes, exercise improves glucose control (as reflected in HbA(1c)) and physical fitness, but it is not clear to what extent these exercise-induced improvements are correlated with one another. We hypothesised that reductions in HbA(1c) would be related: (1) to increases in aerobic fitness and strength respectively in patients performing aerobic training or resistance training; and (2) to changes in strength and aerobic fitness in patients performing aerobic and resistance training.Methods We randomly allocated 251 type 2 diabetes patients to aerobic, resistance, or aerobic plus resistance training, or to a sedentary control group. Peak oxygen consumption (V (V) over dotO(2peak)), workload, treadmill time and ventilatory threshold measurements from maximal treadmill exercise testing were measured at baseline and 6 months. Muscular strength was measured as the maximum weight that could be lifted eight times on the leg press, bench press and seated row exercises.Results With aerobic training, significant associations were found between changes in both (V)over dotO(2peak) (p = 0.040) and workload (p = 0.022), and changes in HbA(1c). With combined training, improvements in (V)over dotO(2peak) (p = 0.008), workload (p = 0.034) and ventilatory threshold (p = 0.003) were significantly associated with changes in HbA1c. Increases in strength on the seated row (p = 0.006) and in mid-thigh muscle cross-sectional area (p = 0.030) were significantly associated with changes in HbA(1c) after resistance exercise, whereas the association between increases in muscle cross-sectional area and HbA(1c) in participants doing aerobic plus resistance exercise (p = 0.059) was of borderline significance.Conclusions/interpretation There appears to be a link between changes in fitness and HbA(1c). The improvements in cardiorespiratory fitness with aerobic training may be a better predictor of changes in HbA(1c) than improvements in strength.