STRESS-ADAPTATION AND ADRENAL ACTIVITY IN ISOLATED AND CROWDED RATS
STRESS-ADAPTATION AND ADRENAL ACTIVITY IN ISOLATED AND CROWDED RATS
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DOI：
10.1016/0031-9384(86)90006-5
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发表时间：
1986-01-01
影响因子：
2.9
通讯作者：
FRAILE, A
中科院分区：
文献类型：
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作者：
GAMALLO, A;VILLANUA, A;FRAILE, A
将社会饲养的雄性对照大鼠（Co）与拥挤饲养的大鼠（Cr）和隔离饲养的大鼠（I）进行比较。测定大鼠对中度应激（旷场试验中活动量和排便速度）的适应性和对强烈应激敏感性抑制溃疡的适应性，并测定大鼠基础肾上腺皮质活性（测定皮质酮（R.I.A.）肾上腺和胸腺的淡水重量。结果表明，在铬和I饲养的大鼠，这导致减少活动的变量，增加排便率和高敏感性约束溃疡的中度和强烈的压力的适应性很差。拥挤条件的影响比隔离条件的影响更大。我们还发现，在隔离和拥挤饲养的大鼠中，肾上腺功能增加，皮质酮的基础分泌值很大，胸腺萎缩，此外，拥挤饲养的动物显示肾上腺肥大。
Socially reared male control rats (Co) were compared with crowded reared rats (Cr) and isolated reared rats (I). We assayed the adaptation to moderate stress (activity and defecation rate in open-field test) and to intensive stress sensitivity to restrain ulcer, so as the basal adrenal activity measuring basal values of corticosterone (R.I.A.) and fresh water weight of adrenal and thymus glands. Results show a great lack of adaptation to moderate and intensive stress in Cr and I reared rats which leads to a decrease of activity of variables, an increase of defecation rates and a high sensitivity to restraint ulcers. The effect of crowding conditions show higher values than isolation. We also found, in isolated and crowded reared rats, an increase in the adrenal function with great values for the basal secretion of corticosterone and atrophy of the thymus gland, besides which, crowded reared animals showed adrenal hypertrophy.