A high-density single-nucleotide polymorphism map of Xq25-q28.
A high-density single-nucleotide polymorphism map of Xq25-q28.
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DOI：
10.1006/geno.2000.6165
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发表时间：
2000-05
期刊：
影响因子：
4.4
通讯作者：
P. Taillon-Miller;P. Kwok
中科院分区：
文献类型：
--
作者：
P. Taillon-Miller;P. Kwok
用一种有针对性的方法发现了Xq25-q28的高密度单核苷酸多态(SNP)图谱。这一高密度图谱包括217个新的SNP标记，其中117个是CEPH亲本群体中具有20%微小等位基因频率的信息性标记。在目标区域，SNP标记之间的平均距离为100kb。这是迄今为止最密集的Xq25-q28基因图谱。SNP标记按其在X染色体上的大小顺序排列，来自当前遗传图谱的标记使用相同的比例放置，以产生该区域的综合图谱。
A high-density single-nucleotide polymorphism (SNP) map was developed for Xq25-q28 using a targeted approach to SNP discovery. This high-density map includes 217 new SNP markers, and 117 are informative in the CEPH parent population with >20% minor allele frequency. The average distance between SNP markers is 100 kb in the targeted regions. This is the densest genetic map of Xq25-q28 to date. The SNP markers are presented in order by their distance in megabases along the X chromosome, and the markers from the current genetic map are placed using the same scale to produce an integrated map of the region.