Dual origin of melanocytes defined by Sox 1 expression and their region-specific distribution in mammalian skin.
Dual origin of melanocytes defined by Sox 1 expression and their region-specific distribution in mammalian skin.
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由 Sox 1 表达及其在哺乳动物皮肤中的区域特异性分布定义的黑色素细胞的双重起源。
DOI：
10.1111/dgd.12034
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Takahiro Kunisada
中科院分区：
文献类型：
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作者：
Naoko Yoshimura;Tsutomu Motohashi;Hitomi Aoki;Ken-ichi Tezuka;Natsuki Watanabe;Takanori Wakaoka;Takumi Era;Takahiro Kunisada
黑素细胞是从背侧神经管分层的神经嵴细胞（NCC）产生的色素产生细胞。被广泛接受的前提是，NCC沿沿着背外侧途径迁移是皮肤中黑素细胞的主要来源，最近受到雪旺细胞前体是皮肤中黑素细胞的主要细胞来源的发现的挑战。尽管如此，在各种脊椎动物胚胎中，黑素细胞完全来自NCC。在这项研究中，我们表明，NCC群体不是来自Sox 1+背神经上皮细胞，而是来自Sox 1 −细胞，它们在小鼠皮肤中分化成大量黑素细胞。后来，这些Sox 1 −细胞明显地与来自Sox 1+背神经上皮细胞来源的NCC的细胞分离。Sox1 −细胞可能起源于表皮细胞，这也加强了它们的非神经上皮起源。
Melanocytes are pigment‐producing cells generated from neural crest cells (NCCs) that delaminate from the dorsal neural tube. The widely accepted premise that NCCs migrating along the dorsolateral pathway are the main source of melanocytes in the skin was recently challenged by the finding that Schwann cell precursors are the major cellular source of melanocytes in the skin. Still, in a wide variety of vertebrate embryos, melanocytes are exclusively derived from NCCs. In this study, we show that a NCC population that is not derived fromSox1+dorsal neuroepithelial cells but are derived fromSox1−cells differentiate into a significant population of melanocytes in the skin of mice. Later, theseSox1−cells clearly segregate from cells that originated fromSox1+dorsal neuroepithelial cell‐derived NCCs. The possible derivation ofSox1−cells from epidermal cells also strengthens their non‐neuroepithelial origin.