Unsaturated fatty acid alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 trafficking.
Unsaturated fatty acid alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 trafficking.
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不饱和脂肪酸通过调节 HMGB1 运输来改变非小细胞肺腺癌的免疫反应。
DOI：
10.1101/2023.11.08.566231
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
SimmonsJr,GlennE
中科院分区：
文献类型：
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作者：
Cole-Skinner,Breanna;Andre,NicoleM;Blankenheim,Zachary;Root,Kate;SimmonsJr,GlennE
癌细胞逃避免疫应答对于癌症发展和转移至关重要。临床医生启动免疫系统以靶向这些流氓细胞的能力是一个不断增长的研究和医学领域。在这项研究中，我们深入研究了非小细胞肺腺癌（NSCLC）中脂质代谢，高迁移率族蛋白1（HMGB 1）和免疫调节之间的关系，为患者提供了新的治疗途径和潜在的个性化方法。我们发现，与正常组织相比，硬脂酰CoA去饱和酶1（SCD 1）在NSCLC肿瘤中的表达降低。这强调了脂质代谢在肿瘤进展中的关键作用。有趣的是，单不饱和脂肪酸（MUFA）的可用性影响了程序性死亡受体配体-1（PD-L1）的表达，PD-L1是肺癌细胞和免疫细胞中的关键免疫检查点靶标，这表明了一种调节免疫反应的新方法。这项研究揭示了HMGB 1，SCD 1和PD-L1之间的复杂相互作用，影响肿瘤的免疫敏感性。我们的工作强调了了解脂质代谢和免疫调节之间的复杂关系以开发更有效的NSCLC治疗和个性化治疗的重要性。随着我们继续探索这些联系，我们希望为不断发展的癌症研究领域做出贡献，改善患者的预后并推进NSCLC的精准医学。
Cancer cell evasion of the immune response is critical to cancer development and metastases. The ability of clinicians to kickstart the immune system to target these rogue cells is an ever-growing area of research and medicine. In this study, we delved into the relationship between lipid metabolism, High Mobility Group Box 1 protein (HMGB1), and immune regulation within non-small cell lung adenocarcinoma (NSCLC), shedding light on novel therapeutic avenues and potential personalized approaches for patients. We found that the expression of stearoyl CoA desaturase 1 (SCD1) was decreased in NSCLC tumors compared to normal tissues. This emphasized the critical role of lipid metabolism in tumor progression. Interestingly, monounsaturated fatty acid (MUFA) availability impacted the expression of programmed death receptor ligand −1 (PD-L1), a pivotal immune checkpoint target in lung cancer cells and immune cells, suggesting a novel approach to modulating the immune response. This study uncovered a complex interplay between HMGB1, SCD1, and PD-L1, influencing the immunological sensitivity of tumors. Our work underscores the importance of understanding the intricate relationships between lipid metabolism and immune modulation to develop more effective NSCLC treatments and personalized therapies. As we continue to explore these connections, we hope to contribute to the ever-evolving field of cancer research, improving patient outcomes and advancing precision medicine in NSCLC.