Environmental PCB exposure and risk of endometriosis
Environmental PCB exposure and risk of endometriosis
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DOI：
10.1093/humrep/deh575
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发表时间：
2005-01-01
影响因子：
6.1
通讯作者：
Kostyniak, PJ
中科院分区：
文献类型：
--
作者：
Louis, GMB;Weiner, JM;Kostyniak, PJ
背景：最近发现激素活性环境因素与子宫内膜异位症的发生有关。方法：我们进行了一项研究来评估子宫内膜异位症（一种雌激素依赖性妇科疾病）与 62 种多氯联苯 (PCB) 同系物之间的关系。我们招募了 84 名年龄在 18-40 岁之间、符合条件的女性，接受腹腔镜检查进行研究，其中包括访谈和血液样本 (n = 79; 94%)。 32 名女性在腹腔镜检查中目视确认子宫内膜异位症，而 52 名女性则没有。血液样本以 14 个批次进行检测，其中包括四个用于毒理学分析的质量控制样本。每种 PCB 同系物均经过调整以回收；减去特定批次的试剂空白。所有 PCB 浓度均进行对数转换，并首先以 ng/g 血清表示为总和，然后根据 PCB 同源物的雌激素或抗雌激素活性表示为三分位数。结果：使用无条件逻辑回归分析。在抗雌激素 PCB 的第三个三分位数中，观察到女性的比值比 (OR) 显着升高 [OR 3.77； 95% 置信区间 (CI) 1.12-12.68]。控制妊娠后风险仍然较高。目前吸烟和血清脂质（OR 3.30；95% CI 0.87-12.46）。结论：这些数据表明，抗雌激素 PCB 可能与子宫内膜异位症的发生有关。
BACKGROUND: Hormonally active environmental agents have recently been associated with the development of endometriosis. METHODS: We undertook a study to assess the relationship between endometriosis, an estrogen-dependent gynaecological disease, and 62 individual polychlorinated biphenyl (PCBs) congeners. We enrolled 84, eligible women aged 18-40 years undergoing laparoscopy for study, which included an interview and blood specimen (n = 79; 94%). Thirty-two women had visually confirmed endometriosis at laparoscopy while 52 did not. Blood specimens were run in batches of 14 including four quality control samples for toxicological analysis. Each PCB congener was adjusted for recovery; batch-specific reagent blanks were subtracted. All PCB concentrations were log transformed and expressed in ng/g serum first as a sum and then as tertiles by purported estrogenic or anti-estrogenic activity of PCB congeners. RESULTS: Using unconditional logistic regression analysis. a significantly elevated odds ratio (OR) was observed for women in the third tertile of anti-estrogenic PCBs [OR 3.77; 95% confidence interval (CI) 1.12-12.68]. Risk remained elevated after controlling for gravidity. current cigarette smoking and serum lipids (OR 3.30; 95% CI 0.87-12.46). CONCLUSIONS: These data suggest that anti-estrogenic PCBs may be associated with the development of endometriosis.