Interleukin 21: a cytokine/cytokine receptor system that has come of age
Interleukin 21: a cytokine/cytokine receptor system that has come of age
复制标题
DOI：
10.1189/jlb.0308149
复制
发表时间：
2008-08-01
影响因子：
5.5
通讯作者：
Spolski, Rosanne
中科院分区：
文献类型：
--
作者：
Leonard, Warren J.;Zeng, Rong;Spolski, Rosanne
白介素21(IL-21)及其受体是第六个细胞因子系统，其作用被认为需要共同的细胞因子受体伽马链。IL-21是由活化的CD4(+)T细胞、自然杀伤T细胞和滤泡T辅助细胞产生的，对一系列淋巴-造血系有作用。在其众多作用中，IL-21对免疫球蛋白的产生和B细胞的终末分化起关键作用，作为T细胞的伴生素，可以驱动CD8(+)T细胞的扩张，可以负向调节树突状细胞的功能，在Th17细胞的分化中起着至关重要的作用。重要的是，IL-21参与了自身免疫的发病机制，并显示出强大的抗肿瘤作用。因此，调节和操纵IL-21活动的能力对免疫调节和人类疾病的治疗具有重要意义。
Interleukin-21 (IL-21) and its receptor represent the sixth cytokine system whose actions were recognized to require the common cytokine receptor gamma chain. IL-21 is produced by activated CD4(+) T cells, natural killer T cells, and follicular T helper cells and has actions on a range of lympho-hematopoietic lineages. Among its many effects, IL-21 serves a critical role for immunoglobulin production and terminal B cell differentiation, acts as a T cell comitogen and can drive the expansion of CD8(+) T cells, can negatively regulate dendritic cell function and plays an essential role in the differentiation of Th17 cells. Importantly, IL-21 is implicated in the pathogenesis of autoimmunity and exhibits potent actions as an antitumor agent. The ability to regulate and manipulate the actions of IL-21, therefore, has important implications for immunoregulation and the therapy of human disease.