Acetic acid enhances endurance capacity of exercise-trained mice by increasing skeletal muscle oxidative properties
Acetic acid enhances endurance capacity of exercise-trained mice by increasing skeletal muscle oxidative properties
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DOI：
10.1080/09168451.2015.1034652
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发表时间：
2015-09-02
影响因子：
1.6
通讯作者：
Kim, Young Jun
中科院分区：
文献类型：
--
作者：
Pan, Jeong Hoon;Kim, Jun Ho;Kim, Young Jun
醋酸已被证明在运动训练期间促进骨骼肌中的糖原补充。本研究采用小鼠在体模型，研究了醋酸对运动训练中耐力和肌肉氧化代谢的影响。在运动小鼠中，乙酸诱导耐力的显着增加，伴随着内脏脂肪库的减少。在运动的小鼠中，乙酸喂养的小鼠的血清非酯化脂肪酸和尿素氮水平显着降低。重要的是，在小鼠中，乙酸显著增加了参与脂肪酸氧化和糖酵解到氧化纤维型转化的关键酶的肌肉表达。综上所述，这些研究结果表明，乙酸通过促进肌肉的氧化特性，部分通过AMPK介导的脂肪酸氧化，提高耐力运动能力，并提供了一个重要的基础上，乙酸作为一个主要组成部分的新的ergogenic艾滋病的应用。
Acetic acid has been shown to promote glycogen replenishment in skeletal muscle during exercise training. In this study, we investigated the effects of acetic acid on endurance capacity and muscle oxidative metabolism in the exercise training using in vivo mice model. In exercised mice, acetic acid induced a significant increase in endurance capacity accompanying a reduction in visceral adipose depots. Serum levels of non-esterified fatty acid and urea nitrogen were significantly lower in acetic acid-fed mice in the exercised mice. Importantly, in the mice, acetic acid significantly increased the muscle expression of key enzymes involved in fatty acid oxidation and glycolytic-to-oxidative fiber-type transformation. Taken together, these findings suggest that acetic acid improves endurance exercise capacity by promoting muscle oxidative properties, in part through the AMPK-mediated fatty acid oxidation and provide an important basis for the application of acetic acid as a major component of novel ergogenic aids.