The continuous measurement of anti-CCP-antibodies does not help to evaluate the disease activity in anti-CCP-antibody-positive patients with rheumatoid arthritis
The continuous measurement of anti-CCP-antibodies does not help to evaluate the disease activity in anti-CCP-antibody-positive patients with rheumatoid arthritis
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DOI：
10.1007/s10067-010-1557-5
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发表时间：
2010-12-01
影响因子：
3.4
通讯作者：
Bergner, Raoul
中科院分区：
文献类型：
--
作者：
Landmann, Thoren;Kehl, Gabriele;Bergner, Raoul
抗环瓜氨酸肽抗体 (CCP-AB) 用于诊断类风湿性关节炎 (RA)。目前尚不清楚 CCP-AB 水平的程度是否有助于评估疾病活动或作为个体活动参数的个体随访。我们调查了 40 名患有已知 RA 且 CCP-AB 呈阳性的患者。分析了所有患者随时间推移的疾病活动度 (DAS 28) 与 CCP-AB 水平量以及个体随访之间的相关性。 CCP-AB 与 DAS 28 之间的相关性较弱 [r=0.19； p=0.001]被发现。 CCP-AB滴度和DAS 28之间的个体相关性范围在r=-1和r=1之间，因此在单个患者中观察到强正相关和强负相关。在糜烂性 RA 患者中，这种相关性显着高于非糜烂性 RA 患者。由于 CCP-AB 水平与 DAS 28 测量的疾病活动参数之间的相关性非常低，因此我们得出结论，要使用简单且已建立的参数（如晨僵、HAQ 或 ESR）来监测疾病活动。目前，对 CCP-AB 水平的个体跟踪对于监测疾病活动尚无用处。
Anti-cyclic citrullinated peptide antibody (CCP-AB) are used for diagnosis of rheumatoid arthritis (RA). It is still unknown if the extent of CCP-AB levels is useful to assess the disease activity or the individual follow-up as an individual activity parameter. We investigated 40 patients with a known RA who were positive for CCP-AB. Correlation between disease activity (DAS 28) and the amount of levels of CCP-AB in all patients over time as well as the individual follow-up were analysed. A weak correlation between CCP-AB and DAS 28 [r=0.19; p=0.001] was found. The individual correlation between CCP-AB titre and DAS 28 ranged between r=-1 and r=1, so a strong positive and also a strong negative correlation was seen in single patients. In patients with erosive RA the correlation was significantly more positive than in patients with non-erosive RA. Because the correlation between CCP-AB levels and parameters of disease activity measured by DAS 28 is very low, we conclude for monitoring the disease activity to use simply and established parameters like morning stiffness, HAQ or ESR. The individual follow-up of the levels of CCP-AB is by the moment not useful for monitoring the disease activity.