Nanoengineered device for drug delivery application
Nanoengineered device for drug delivery application
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DOI：
10.1088/0957-4484/15/10/015
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发表时间：
2004-10
期刊：
影响因子：
3.5
通讯作者：
P. Sinha;G. J. Valco;Sadhana Sharma;Xuewu Liu;M. Ferrari
中科院分区：
文献类型：
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作者：
P. Sinha;G. J. Valco;Sadhana Sharma;Xuewu Liu;M. Ferrari
开发了一种高精度纳米工程设备，可以产生用于治疗应用的药物的长期零级释放。该器件包含在两个直接键合的硅片之间制造的纳米通道，因此具有很高的机械强度。该制造基于选择性生长氧化物然后将其去除，从而通过在氧化物生长期间消耗特定的硅层来定义纳米通道。通过纳米通道的扩散是药物释放的速率限制步骤。通过这种纳米通道释放的葡萄糖的测量验证了零级释放曲线。介绍了器件设计、制造细节以及通过 60 nm 通道的葡萄糖释放曲线。
A high precision nanoengineered device was developed to yield long term zero-order release of drugs for therapeutic applications. The device contains nanochannels that were fabricated in between two directly bonded silicon wafers and therefore poses high mechanical strength. The fabrication is based upon selectively growing oxide and then removing it, and thus defining nanochannels by consuming a specified layer of silicon during oxide growth. Diffusion through the nanochannels is the rate limiting step for the release of drugs. A measurement of glucose released through such nanochannels validates the zero-order release profile. Device design, fabrication details and the glucose release profile through 60 nm channels are presented.