The a-wave of the dark adapted electroretinogram in glaucomas: are photoreceptors affected?
The a-wave of the dark adapted electroretinogram in glaucomas: are photoreceptors affected?
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DOI：
10.1136/bjo.85.4.397
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发表时间：
2001-04-01
影响因子：
4.1
通讯作者：
Horn, FK
中科院分区：
文献类型：
--
作者：
Velten, IM;Korth, M;Horn, FK
Aims-To评估是否暗适应闪光视网膜电图（ERG）的a波是由cardiomatous damage. Methods-ERG记录20例（年龄33-65岁）晚期cardiomas（原发性和继发性开角型和低张力cardiomas）和20名正常人使用ganzfeld刺激。经过30分钟的暗适应和瞳孔直径扩大到至少7.5 mm后，获得亮度响应函数，呈现出暗视亮度增加的白色闪光（最高闪光强度为9.4 cd/s/m（2），最低为5.75 log单位，低于该强度），闪光间隔为5秒。对于每个暗视亮度，对四次闪光的响应进行平均。在10，11，和12毫秒测量a波的振幅。在青光眼组内，a波的振幅和静态视野检查（Octopus 500周长，程序G1）的平均偏差的眼间差异之间的相关性计算所有闪光强度。在正常人和青光眼患者之间，比较所有闪光强度的a波振幅（配对t检验）。结果在青光眼组内，a波振幅的眼间差异与闪光强度为9.4、5.3、1.7和0.5 cd/s/m2时的MD差异显著相关。在闪光强度为9.4和5.3 cd/s/m2时，青光眼患者的a波振幅明显低于正常组（p < 0.005）。结论：这些电生理结果表明，青光眼损伤也可能影响视网膜的外部结构，尤其是感光细胞。
Aims-To evaluate whether the a-wave of the dark adapted flash electroretinogram (ERG) is affected by glaucomatous damage.Methods-ERGs were recorded in 20 patients (age 33-65 years) with advanced glaucomas (primary and secondary open angle and low tension glaucomas) and 20 normals using a ganzfeld stimulus. After 30 minutes of dark adaptation and pupil dilatation to at least 7.5 mm in diameter, luminance response functions were obtained presenting white flashes of increasing scotopic luminance (the highest flash intensity being 9.4 cd/s/m(2), the lowest being 5.75 log units below it) with an interflash interval of 5 seconds. For each scotopic luminance, the responses of four flashes were averaged. The a-wave's amplitude was measured at 10, 11, and 12 ms. Within the glaucoma group, correlations between the interocular differences of the a-wave's amplitude and the mean deviation of a static perimetry (Octopus 500 perimeter, program G1) were computed for all flash intensities. Between normals and glaucomas, the a-wave's amplitude was compared for all flash intensities (paired t test).Results-Within the glaucoma group, the interocular differences of the a-wave's amplitudes correlated significantly with the differences of the MD for flash intensities of 9.4, 5.3, 1.7, and 0.5 cd/s/m(2). The a-wave's amplitude was significantly lower in the glaucoma compared with the normal group (p < 0.005) for flash intensities of 9.4 and 5.3 cd/s/m(2).Conclusion-These electrophysiological results imply that also the outer retinal structures, especially the photoreceptors, may be affected by glaucomatous damage.