Heterogeneous distribution of acidic TA-4 in cervical squamous cell carcinoma: immunohistochemical demonstration with monoclonal antibodies.
Heterogeneous distribution of acidic TA-4 in cervical squamous cell carcinoma: immunohistochemical demonstration with monoclonal antibodies.
复制标题
酸性 TA-4 在宫颈鳞状细胞癌中的异质分布：用单克隆抗体进行免疫组织化学演示。
DOI：
10.20772/cancersci1985.78.11_1246
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Isao Ikeda
中科院分区：
文献类型：
--
作者：
H. Kato;Y. Suehiro;H. Morioka;T. Torigoe;Myoga Akio;Kiyosi Sekiguchi;Isao Ikeda
肿瘤抗原TA-4分为两个亚组：酸性和中性TA-4。通过使用单克隆抗体检查这些TA-4亚组的组织定位，即，与酸性和中性TA-4均反应的Mab-21，以及对酸性TA-4具有特异性的Mab-317。用Mab-21的免疫组织化学染色显示在癌巢的大部分部分和子宫颈的非癌鳞状上皮的中间层中的阳性细胞，而用Mab-317的阳性染色仅在邻近周围基质组织的癌巢的周边部分的细胞中观察到。因此，TA-4亚群的检测可能有助于研究鳞状细胞的生物学行为。
Tumor antigen TA-4 is divided into two subgroups; acidic and neutral TA-4. The tissue localizations of these TA-4 subgroups were examined by using monoclonal antibodies, i.e., Mab-21 which reacts with both acidic and neutral TA-4, and Mab-317 which is specific to acidic TA-4. Immunohistochemical staining with Mab-21 showed positive cells in most parts of the cancer nest and in the intermediate layer of the non-cancerous squamous epithelium of the uterine cervix, whereas positive staining with Mab-317 was observed only in the cells at the peripheral parts of the cancer nest adjacent to the surrounding stromal tissue. Thus, examination of the subgroups of TA-4 may be a useful aid for investigating the biologic behavior of squamous cells.