Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.
Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.
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发表时间：
2010
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通讯作者：
Liang Feng;X. Jia;Mao-mao Zhu;Yan Chen;F. Shi
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作者：
Liang Feng;X. Jia;Mao-mao Zhu;Yan Chen;F. Shi
化学预防是降低非小细胞肺癌（NSCLC）发病率和死亡率的可行途径之一。本研究旨在探讨夏枯草对非小细胞肺癌的化学预防作用机制。(PV)使用60%乙醇的PV提取物（P-60）。在A/J小鼠模型中，P-60组显著降低苯并[a]芘诱导的肺肿瘤。此外，P-60还具有调节细胞周期和诱导SPC-A-1细胞凋亡的能力。因此，我们认为P-60具有作为肺癌化学预防剂的潜力。
Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.