The chronic and evolving neurological consequences of traumatic brain injury.
The chronic and evolving neurological consequences of traumatic brain injury.
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DOI：
10.1016/s1474-4422(17)30279-x
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发表时间：
2017-10
期刊：
影响因子：
48
通讯作者：
Polinder, Suzanne
中科院分区：
文献类型：
--
作者：
Wilson, Lindsay;Stewart, William;Dams-O'Connor, Kristen;Diaz-Arrastia, Ramon;Horton, Lindsay;Menon, David K.;Polinder, Suzanne
创伤性脑损伤 (TBI) 可能对健康和福祉产生终生动态影响。关于长期后果的研究强调，对于许多患者来说，TBI 应被视为一种慢性健康状况。有证据表明，TBI 后的功能结果可以在受伤后长达二十年的时间内表现出改善或恶化，并且全因死亡率多年来一直保持较高水平。此外，TBI 是多种神经系统疾病的危险因素，包括癫痫、中风和神经退行性疾病。关于 TBI 后的神经退行性变，对损伤后长期神经病理学的尸检研究发现了复杂的持续存在和演变的异常，最好将其描述为多病理学，其中包括慢性创伤性脑病。尽管人们越来越意识到 TBI 的终生后果，但研究方面仍存在巨大差距。因此，需要进一步了解慢性病理学及其对 TBI 幸存者的影响，这可以为这一庞大患者群体的长期健康管理提供信息。
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualized as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology which includes chronic traumatic encephalopathy. Despite growing awareness of the life-long consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.