Sepsis redefined: the search for surrogate markers.
Sepsis redefined: the search for surrogate markers.
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DOI：
10.1016/s0924-8579(09)70560-6
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发表时间：
2009-01-01
影响因子：
10.8
通讯作者：
Woods, Christopher W
中科院分区：
文献类型：
--
作者：
Tsalik, Ephraim L;Woods, Christopher W
脓毒症是一种常见且严重的疾病，具有较高的发病率、死亡率以及相关成本。此外，在过去三十年中，脓毒症的发病率每年都在上升，其发病率和死亡率仍然很高。脓毒症的异质性使其治疗更加复杂。这不仅体现在致病病原体方面，还体现在宿主反应的性质和严重程度以及其临床表现上。因此，寻找脓毒症替代标志物的工作一直是一项艰巨的任务。在本文中，我们回顾历史，对各种脓毒症标志物提出一些见解，阐述与它们的使用和解读相关的优势和注意事项。我们还讨论了功能基因组学的现状，这是一项相对较新的技术进步，它已经开始改变我们对脓毒症病理生理学的理解，并为开发更敏感、更特异的脓毒症生物标志物提供了新的方向。
Sepsis is a common and severe medical condition with substantial associated morbidity, mortality and cost. Furthermore, the incidence of sepsis has been rising annually over the past three decades, and morbidity and mortality remain high. The management of sepsis is further complicated by its very heterogeneous nature. This extends not only to the offending pathogens, but also to the nature and severity of the host response as well as its clinical manifestations. Efforts to identify surrogate markers for sepsis have therefore been an ongoing struggle. In this article we present some insights into various sepsis markers through history, presenting advantages and caveats associated with their use and interpretation. We also discuss the state of functional genomics, a relatively recent technological advancement that has already begun to change our understanding of sepsis pathophysiology, and offer new directions in the development of a more sensitive and specific sepsis biomarker.