Psychological correlates of sexual dysfunction in female rectal and anal cancer survivors: analysis of baseline intervention data.
Psychological correlates of sexual dysfunction in female rectal and anal cancer survivors: analysis of baseline intervention data.
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女性直肠癌和肛门癌幸存者性功能障碍的心理相关性：基线干预数据分析。
DOI：
10.1111/jsm.12152
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
DuHamel,Katherine
中科院分区：
文献类型：
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作者：
Philip,ErrolJ;Nelson,Christian;Temple,Larissa;Carter,Jeanne;Schover,Leslie;Jennings,Sabrina;Jandorf,Lina;Starr,Tatiana;Baser,Ray;DuHamel,Katherine
简介性功能障碍是一种复杂的多因素结构，可影响男性和女性，并且在直肠癌和肛门癌治疗后通常会显着恶化。尽管如此，它在癌症生存领域仍然是一个研究不足、报告不足和治疗不足的问题。目的本研究检查了参加治疗性功能障碍的干预试验的女性的特征，并探讨了性功能和心理健康之间的关系。方法作为当前研究的一部分，对 70 名治疗后肛门癌或直肠癌幸存者进行了评估。参与者参加了一项治疗性功能障碍的随机干预试验，并在随机分组前完成了结局指标。 主要结局指标 主要结局指标是生活质量 (QOL)（欧洲癌症研究和治疗组织核心生活质量问卷 [EORTC-QLQ-C30] 和结直肠癌特异性模块 [QLQ-CR38]）、性功能（女性性功能） 指数）和心理健康（简要症状清单抑郁/焦虑、事件影响量表修订版、CR-38 身体意象）。 结果参与研究干预的女性平均年龄 55 岁，主要是白人 (79%)，已婚 (57%)，初次治疗后平均年龄为 4 年。对于那些在基线时报告性活动的人（N = 41），性功能障碍与一系列特定的心理健康指标相关，所有这些都与假设的方向有关。性/关系满意度分量表与所有心理健康指标相关（r= -0.45 至 -0.70，所有 P< 0.01）。身体形象、焦虑和癌症特异性创伤后困扰与性功能分量表的相关性显着，而全球生活质量测量在很大程度上无关。结论对于参加性健康干预的性活跃女性直肠癌和肛门癌幸存者，性功能障碍与特定的心理健康测量显着且一致地相关，最显着的是性/关系满意度。这些结果表明，除了广泛的生活质量评估之外，性功能可能需要提供者进行重点评估，并且对性/关系满意度的关注对于针对这组患者制定和实施干预措施可能至关重要。
IntroductionSexual dysfunction represents a complex and multifactorial construct that can affect both men and women and has been noted to often deteriorate significantly after treatment for rectal and anal cancer. Despite this, it remains an understudied, underreported, and undertreated issue in the field of cancer survivorship.AimThis study examined the characteristics of women enrolled in an intervention trial to treat sexual dysfunction, and explored the relationship between sexual functioning and psychological well‐being.MethodsThere were 70 female posttreatment anal or rectal cancer survivors assessed as part of the current study. Participants were enrolled in a randomized intervention trial to treat sexual dysfunction and completed outcome measures prior to randomization.Main Outcomes MeasuresThe main outcome measures are quality of life (QOL) (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC‐QLQ‐C30] and Colorectal Cancer‐Specific Module [QLQ‐CR38]), sexual functioning (Female Sexual Functioning Index), and psychological well‐being (Brief Symptom Inventory Depression/Anxiety, Impact of Events Scale‐Revised, CR‐38 Body Image).ResultsWomen enrolled in the study intervention were on average 55 years old, predominantly Caucasian (79%), married (57%), and a median of 4 years postprimary treatment. For those reporting sexual activity at baseline (N = 41), sexual dysfunction was associated with a range of specific measures of psychological well‐being, all in the hypothesized direction. The Sexual/Relationship Satisfaction subscale was associated with all measures of psychological well‐being (r= −0.45 to −0.70, allP< 0.01). Body image, anxiety, and cancer‐specific posttraumatic distress were notable in their association with subscales of sexual functioning, while a global QOL measure was largely unrelated.ConclusionsFor sexually active female rectal and anal cancer survivors enrolled in a sexual health intervention, sexual dysfunction was significantly and consistently associated with specific measures of psychological well‐being, most notably Sexual/Relationship Satisfaction. These results suggest that sexual functioning may require focused assessment by providers, beyond broad QOL assessments, and that attention to Sexual/Relationship Satisfaction may be critical in the development and implementation of interventions for this cohort of patients.